(R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol

Base Information

Chemical Name:(R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol
CAS No.:131180-49-9
Molecular Formula:C17H19Cl2NO
Molecular Weight:324.24486
Hs Code.:2933990090
DSSTox Substance ID:DTXSID701230647
Mol file:131180-49-9.mol

Synonyms:131180-49-9;(R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol;SCHEMBL9227056;DTXSID701230647

Suppliers and Price of (R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL 95.00%
100MG
$ 1843.38

American Custom Chemicals Corporation
BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL 95.00%
50MG
$ 1394.66

Total 2 raw suppliers

Chemical Property of (R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol

Chemical Property:

Refractive Index: ">
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：32.26000
Density:g/cm³
LogP:4.31010
XLogP3:3.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:321.0687196
Heavy Atom Count:21
Complexity:314

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)C(C2=CC=C(C=C2)Cl)(C3=CC=C(C=C3)Cl)O
Isomeric SMILES:C1C[C@H](NC1)C(C2=CC=C(C=C2)Cl)(C3=CC=C(C=C3)Cl)O

Technology Process of (R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol

There total 1 articles about (R)-Bis(4-chlorophenyl)(pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 45736-33-2
(S)-proline-N-carboxyanhydride

: 131180-49-9
(S)-α,α-Bis(4-chlorophenyl)-2-pyrrolidinemethanol

Guidance literature:: In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00002a049

Reference yield: 90.0%

: 5862-32-8
2,6-bis(chloromethyl)-4-methylphenol

: 131180-49-9
(S)-α,α-Bis(4-chlorophenyl)-2-pyrrolidinemethanol

: (S,S)-2,6-bis{2-[hydroxybis(4-chlorophenyl)methyl]pyrrolidin-1-ylmethyl}-4-methylphenol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/chem.200401159

Reference yield: 74.0%

: 131180-49-9
(S)-α,α-Bis(4-chlorophenyl)-2-pyrrolidinemethanol

: 2950-83-6
4-(2,4-dioxo-1,2,3,4-tetrahydro-1-pyrimidinyl)butanoic acid

: 1204659-14-2
(S)-1-(4-(2-(bis(4-chlorophenyl)(hydroxy)methyl)pyrrolidin-1-yl)-4-oxobutyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm201627n