Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI)
• CAS No.: 131262-35-6
• Molecular Formula: C6H8F2O2
• Molecular Weight: 150.1233264
• Mol file: 131262-35-6.mol

Synonyms:Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI)

Chemical Property:

• PSA: 37.30000
• LogP: 1.36230

Purity/Quality:

99% ^*data from raw suppliers

2,2-Difluoro-3,3-dimethylcyclopropanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI)

There total 6 articles about Cyclopropanecarboxylic acid, 2,2-difluoro-3,3-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Methyl 2,2-Difluoro-3,3-dimethyl-1-cyclopropanecarboxylate (131262-36-7) → 2,2-Difluoro-3,3-dimethyl-1-cyclopropanecarboxylic Acid (131262-35-6)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃;

DOI:10.1002/adsc.201801006

Reference yield: 85.0%

1,1-Difluoro-3-hydroxymethyl-2,2-dimethylcyclopropane (131262-12-9) → 2,2-Difluoro-3,3-dimethyl-1-cyclopropanecarboxylic Acid (131262-35-6)

Guidance literature:

With sodium hydroxide; potassium permanganate; In water; at 25 ℃; for 1h;

DOI:10.1016/S0040-4020(01)87829-7

Reference yield:

1,1-Difluoro-2,2-dimethyl-3-(2-tetrahydropyranyloxymethyl)-cyclopropane (131262-22-1) → 2,2-Difluoro-3,3-dimethyl-1-cyclopropanecarboxylic Acid (131262-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / p-toluenesulfonic acid, glycerine / 4 h / up to 100 deg C

2: 85 percent / KMnO₄, NaOH / H₂O / 1 h / 25 °C

With sodium hydroxide; potassium permanganate; toluene-4-sulfonic acid; glycerol; In water;

DOI:10.1016/S0040-4020(01)87829-7

upstream raw materials:

1,1-Difluoro-3-hydroxymethyl-2,2-dimethylcyclopropane

1,1-Difluoro-2,2-dimethyl-3-(2-tetrahydropyranyloxymethyl)-cyclopropane

1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-butene

3-methyl-2-buten-1-ol

Downstream raw materials:

(3-Phenoxy)benzyl 2,2-Difluoro-3,3-dimethyl-1-cyclopropanecarboxylate