1-Propanethiol,2,3-bis[(2-mercaptoethyl)thio]-

Base Information

• Chemical Name: 1-Propanethiol,2,3-bis[(2-mercaptoethyl)thio]-
• CAS No.: 131538-00-6
• Molecular Formula: C7H16 S5
• Molecular Weight: 260.534
• Mol file: 131538-00-6.mol

Synonyms:1,2-Bis[(2-mercaptoethyl)thio]-3-mercaptopropane;2,3-Bis[(2-mercaptoethyl)thio]-1-propanethiol; 4-(Mercaptomethyl)-1,8-dimercapto-3,6-dithiaoctane;4-(Mercaptomethyl)-3,6-dithia-1,8-octanedithiol; GST

Chemical Property of 1-Propanethiol,2,3-bis[(2-mercaptoethyl)thio]-

Chemical Property:

• Vapor Pressure: 56.2Pa at 20℃
• Boiling Point: 395.6±42.0 °C(Predicted)
• PKA: 9.57±0.10(Predicted)
• PSA: 167.00000
• Density: 1.214
• LogP: 2.61080
• Solubility.: 13190 in mg/100g standard fat at 20 ℃
• Water Solubility.: 12mg/L at 20℃

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-48/22-50/53
• Safety Statements: 23-24/25-36-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3-bis(2-mercaptoethyl)thio)-1-propanethiol is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 1-Propanethiol,2,3-bis[(2-mercaptoethyl)thio]-

There total 11 articles about 1-Propanethiol,2,3-bis[(2-mercaptoethyl)thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,3-bis(2-hydroxyethyl-thio)-1-propanol + thiourea (17356-08-0) → 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane (131538-00-6)

Guidance literature:

2,3-bis(2-hydroxyethyl-thio)-1-propanol; thiourea; With hydrogenchloride; In water; at 110 ℃; for 6h;

With ammonium hydroxide; In toluene; at 75 ℃; for 1h;

Reference yield: 92.5%

C7H13Cl3S2 (63905-12-4) → 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane (131538-00-6)

Guidance literature:

With hydrogen sulfide; sodium hydrogencarbonate; In water; at 90 ℃; pH=8; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;

Reference yield: 87.7%

2-hydroxyethanethiol (60-24-2) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane (131538-00-6)

Guidance literature:

2-hydroxyethanethiol; epichlorohydrin; With sodium hydroxide; In water; at 30 ℃; for 4.5h;

With hydrogenchloride; thiourea; In water; at 110 ℃; for 3h;

With ammonium hydroxide; In toluene; at 60 ℃;

upstream raw materials:

2-hydroxyethanethiol

epichlorohydrin

1,3-bis(2-hydroxyethylthio)-2-propanol

thiourea

Refernces

• 1、 -. "METHOD FOR PRODUCING POLYTHIOL COMPOUND, METHOD FOR PRODUCING CURABLE COMPOSITION, AND METHOD FOR PRODUCING CURED PRODUCT". Paragraph 0083; 0084; 0086; 0087. . Retrieved 2019/03/08.
• 2、 -. "(POLY)THIOL COMPOUND PRODUCTION METHOD". Paragraph 0089-0092. . Retrieved 2019/12/13.