2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI)

Base Information

Chemical Name:2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI)
CAS No.:131669-74-4
Molecular Formula:C₆H₉NO₄
Molecular Weight:159.142
Hs Code.:
Mol file:131669-74-4.mol

Synonyms:2,3-Pyrrolidinedicarboxylicacid, trans-(?à)-;trans-(?à)-Pyrrolidine-2,3-dicarboxylicacid

Suppliers and Price of 2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI)

Chemical Property:

Boiling Point:420.3±45.0 °C(Predicted)
PKA:1.95±0.40(Predicted)
PSA：86.63000
Density:1.456±0.06 g/cm3(Predicted)
LogP:-0.53750

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI)

There total 33 articles about 2,3-Pyrrolidinedicarboxylicacid,(2R,3R)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-Pyrrolidine-1,2,3-tricarboxylic acid 1-benzyl ester

: 131669-74-4,147235-95-8,147332-07-8,147332-08-9,147332-09-0,147332-10-3
(+/-)-Pyrrolidine-2,3-dicarboxylic acid

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; for 12h; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(97)00238-4

Reference yield:

: (1R,5S)-7,7-Dichloro-6-oxo-2-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 131669-74-4,147235-95-8,147332-07-8,147332-08-9,147332-09-0,147332-10-3
(+/-)-Pyrrolidine-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Me₂CuLi / tetrahydrofuran / -50 deg C, 50 min; -50 deg C -> r.t., 3 h

2: 1.) O₃; 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C; 2.) -78 deg C -> r.t., 12 h

3: H₂ / Pd(OH)2 / methanol / 12 h / Ambient temperature

With dimethylsulfide; lithium dimethylcuprate; hydrogen; ozone; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(97)00238-4

Reference yield:

: (1R,5S)-7,7-Dichloro-6-oxo-2-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 131669-74-4,147235-95-8,147332-07-8,147332-08-9,147332-09-0,147332-10-3
(+/-)-Pyrrolidine-2,3-dicarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Me₂CuLi / tetrahydrofuran / -50 deg C, 50 min; -50 deg C -> r.t., 3 h

2: 1.) O₃; 2.) Me₂S / 1.) CH₂Cl₂, MeOH, -78 deg C; 2.) -78 deg C -> r.t., 12 h

3: methanol; diethyl ether / 0.25 h / 0 °C

4: H₂ / Pd(OH)2 / methanol / 12 h / Ambient temperature

5: 6M HCl, Dowex 50-X₈ / 12 h / 70 °C

With hydrogenchloride; dimethylsulfide; Dowex 50-X₈; lithium dimethylcuprate; hydrogen; ozone; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/S0040-4039(97)00238-4