2-M-HYDROXY PACLITAXEL

Base Information

• Chemical Name: 2-M-HYDROXY PACLITAXEL
• CAS No.: 132160-31-7
• Molecular Formula: C47H51NO15
• Molecular Weight: 869.91
• Mol file: 132160-31-7.mol

Synonyms:2-M-HYDROXY PACLITAXEL

Chemical Property of 2-M-HYDROXY PACLITAXEL

Chemical Property:

• PSA: 241.52000
• LogP: 3.83220

Purity/Quality:

98%min ^*data from raw suppliers

2-m-Hydroxy(benzoyl)Paclitaxel ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-m-Hydroxy Paclitaxel is a metabolite of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi''s sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

Technology Process of 2-M-HYDROXY PACLITAXEL

There total 7 articles about 2-M-HYDROXY PACLITAXEL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

taxol (33069-62-4) → 2-O-debenzoyl-2-O-(3-hydroxybenzoyl)paclitaxel (132160-31-7)

Guidance literature:

Multi-step reaction with 5 steps

1: imidazole / dimethylformamide / 2 h / 60 °C

2: imidazole / dimethylformamide / 1 h / Ambient temperature

3: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

4: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

5: HCl, MeOH / Ambient temperature

With 1H-imidazole; hydrogenchloride; methanol; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980229d

Reference yield:

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → 2-O-debenzoyl-2-O-(3-hydroxybenzoyl)paclitaxel (132160-31-7)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

3: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

4: HCl, MeOH / Ambient temperature

With 1H-imidazole; hydrogenchloride; methanol; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980229d

Reference yield:

2'-(tert-butyldimethylsilyl)-7-(triethylsilyl)paclitaxel (156413-61-5) → 2-O-debenzoyl-2-O-(3-hydroxybenzoyl)paclitaxel (132160-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / PhCH₂NMe₃OH / CH₂Cl₂ / -78 - -10 °C

2: 1.) DCC, PP / 1.) toluene, RT, 5 min, 2.) toluene

3: HCl, MeOH / Ambient temperature

With hydrogenchloride; methanol; N-benzyl-trimethylammonium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm980229d

upstream raw materials:

2-O-[3-(benzyloxy)benzoyl]-2-O-(debenzoyl)paclitaxel

C₅₉H₇₉NO₁₅Si₂

taxol

2'-O-(tert-butyldimethylsilyl)paclitaxel