3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI)

Base Information

• Chemical Name: 3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI)
• CAS No.: 132439-88-4
• Molecular Formula: C8H13NO2
• Molecular Weight: 0
• Mol file: 132439-88-4.mol

Synonyms:3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI)

Chemical Property of 3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI)

Chemical Property:

• PSA: 30.82000
• LogP: 0.47920

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI)

There total 3 articles about 3H,6H-Furo[3,4-c]isoxazole,3a,4-dihydro-6-(1-methylethyl)-,trans-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(allyloxy)-3-methyl-1-nitrobutane (132439-79-3) → cis-3a,4-dihydro-6-isopropyl-3H,6H-furo<3,4-c>isoxazole (132439-87-3) + trans-3a,4-dihydro-6-isopropyl-3H,6H-furo<3,4-c>isoxazole (132439-88-4)

Guidance literature:

With phenyl isocyanate; trimethylamine; In benzene; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

Reference yield:

phenyl isocyanate (103-71-9) + 2-(allyloxy)-3-methyl-1-nitrobutane (132439-79-3) → cis-3a,4-dihydro-6-isopropyl-3H,6H-furo<3,4-c>isoxazole (132439-87-3) + trans-3a,4-dihydro-6-isopropyl-3H,6H-furo<3,4-c>isoxazole (132439-88-4)

Guidance literature:

With triethylamine; In benzene; Ambient temperature; other substrates; diastereoselectivity;

DOI:10.1016/S0040-4039(00)92143-9

Reference yield:

3-methyl-1-nitrobutan-2-yl acetate (41367-90-2) → trans-3a,4-dihydro-6-isopropyl-3H,6H-furo<3,4-c>isoxazole (132439-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium tert-butoxide / 1.) THF, -10 to -20 deg C, 2.) 15 min

2: trimethylamine, phenyl isocyanate / benzene / 48 h / Ambient temperature

With potassium tert-butylate; phenyl isocyanate; trimethylamine; In benzene;

upstream raw materials:

phenyl isocyanate

2-(allyloxy)-3-methyl-1-nitrobutane

3-methyl-1-nitrobutan-2-yl acetate