N-(2-((2-Aminoethyl)amino)ethyl)salicylamide

Base Information

• Chemical Name: N-(2-((2-Aminoethyl)amino)ethyl)salicylamide
• CAS No.: 76274-44-7
• Molecular Formula: C11H17 N3 O2
• Molecular Weight: 223.275
• Hs Code.: 2924299090
• European Community (EC) Number: 278-411-1
• DSSTox Substance ID: DTXSID40997627
• Nikkaji Number: J319.300D
• Wikidata: Q82989838
• Mol file: 76274-44-7.mol

Synonyms:76274-44-7;EINECS 278-411-1;N-(2-((2-Aminoethyl)amino)ethyl)salicylamide;N-[2-[(2-AMINOETHYL)AMINO]ETHYL]SALICYLAMIDE;SCHEMBL11407944;DTXSID40997627;N-[2-[(2-Aminoethyl)amino]ethyl]-2-hydroxybenzamide;N-{2-[(2-Aminoethyl)amino]ethyl}-2-hydroxybenzene-1-carboximidic acid

Chemical Property of N-(2-((2-Aminoethyl)amino)ethyl)salicylamide

Chemical Property:

• Vapor Pressure: 1.81E-09mmHg at 25°C
• Boiling Point: 470.3°C at 760 mmHg
• Flash Point: 238.2°C
• PSA: 90.87000
• Density: 1.173g/cm³
• LogP: 1.33630
• XLogP3: 0
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 223.132076794
• Heavy Atom Count: 16
• Complexity: 211

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NCCNCCN)O

Technology Process of N-(2-((2-Aminoethyl)amino)ethyl)salicylamide

There total 3 articles about N-(2-((2-Aminoethyl)amino)ethyl)salicylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

phenyl Salicylate (118-55-8) + 3-azapentane-1,5-diamine (111-40-0,98824-35-2) → N-{2-[(2-aminoethyl)amino]ethyl}salicylamide (76274-44-7)

Guidance literature:

phenyl Salicylate; 3-azapentane-1,5-diamine; for 0.5h; Reflux;

With 2,4,6-Trinitrophenol; In methanol;

DOI:10.1016/j.poly.2018.06.056

Reference yield:

2-hydroxy-N-[2-((2-[(2-hydroxybenzoyl)amino]ethyl)amino)ethyl]benzamide (76218-93-4) → N-{2-[(2-aminoethyl)amino]ethyl}salicylamide (76274-44-7) + salicylic acid (69-72-7,25496-36-0,8052-31-1)

Guidance literature:

With water; sodium hydroxide; In methanol; at 40 ℃; Temperature; Kinetics;

DOI:10.1007/s12039-011-0084-5

Reference yield:

→ N-{2-[(2-aminoethyl)amino]ethyl}salicylamide (76274-44-7)

Guidance literature:

Salicylsaeure-aethylester, Diaethylendiamin;

upstream raw materials:

2-hydroxy-N-[2-((2-[(2-hydroxybenzoyl)amino]ethyl)amino)ethyl]benzamide

phenyl Salicylate

3-azapentane-1,5-diamine