2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid

Base Information

Chemical Name:2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid
CAS No.:134309-86-7
Molecular Formula:C₁₀H₁₃NO₄
Molecular Weight:211.218
Hs Code.:2922509090
DSSTox Substance ID:DTXSID40398918
ChEMBL ID:CHEMBL3273171
Mol file:134309-86-7.mol

Synonyms:2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid;134309-86-7;alpha-Hydroxymethyl-D-tyrosine;(-)-alpha-[HYDROXYMETHYL]TYROSINE;(+)-alpha-Hydroxymethyl tyrosine;Oxyphenylmethylserin;SCHEMBL3117439;CHEMBL3273171;DTXSID40398918;(R)-alpha-(Hydroxymethyl)tyrosine;(S)-alpha-(Hydroxymethyl)tyrosine;FT-0775079

Suppliers and Price of 2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
α-Hydroxymethyl-D-tyrosine
10mg
$ 496.00

TRC
α-Hydroxymethyl-D-tyrosine
100mg
$ 1540.00

Crysdot
(R)-2-Amino-3-hydroxy-2-(4-hydroxybenzyl)propanoicacid 95+%
1g
$ 772.00

American Custom Chemicals Corporation
ALPHA-HYDROXYMETHYL-D-TYROSINE 95.00%
5MG
$ 500.94

Total 2 raw suppliers

Chemical Property of 2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid

Chemical Property:

Vapor Pressure:1.22E-10mmHg at 25°C
Melting Point:284 - 285 °C (ethanol)
Refractive Index:1.635
Boiling Point:495.6°Cat760mmHg
PKA:1.83±0.16(Predicted)
Flash Point:253.5°C
PSA：103.78000
Density:1.412g/cm³
LogP:0.40940
Storage Temp.:2-8°C
XLogP3:-2.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:211.08445790
Heavy Atom Count:15
Complexity:226

Purity/Quality:

99% ^*data from raw suppliers

α-Hydroxymethyl-D-tyrosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(CO)(C(=O)O)N)O
Uses (-)-ALPHA-[HYDROXYMETHYL]TYROSINE is an derivative of D-Tyrosine (T899970), the stereoisomer to L-Tyrosine (T899975) and an amino acid used in various organic syntheses for antibiotics. α-Hydroxymethyl-D-tyrosine is an derivative of D-Tyrosine (T899970), the stereoisomer to L-Tyrosine (T899975) and an amino acid used in various organic syntheses for antibiotics.

Technology Process of 2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid

There total 12 articles about 2-amino-2-(hydroxymethyl)-3-(4-hydroxyphenyl)propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 134255-19-9,134255-20-2,134255-21-3
(+)-N-benzoyl-α-hydroxymethyltyrosine

: 55137-55-8,69980-43-4,69980-45-6,134309-86-7
(+)-α-hydroxymethyltyrosine

Guidance literature:: With hydrogenchloride; for 5h; Heating;
DOI:10.1007/BF01161067

Reference yield:

: 97485-13-7
2-benzamido-3-(4-(benzoyloxy)phenyl)propanoic acid

: 55137-55-8,69980-43-4,69980-45-6,134309-86-7
(-)-α-hydroxymethyltyrosine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / Heating

2: pyridine / propan-2-ol / 3 h / Ambient temperature

3: 90 percent / NaOH / acetone / 3 h / Ambient temperature

5: HCl / 5 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; acetic anhydride; In isopropyl alcohol; acetone;
DOI:10.1007/BF01161067

Reference yield:

: 97485-13-7
2-benzamido-3-(4-(benzoyloxy)phenyl)propanoic acid

: 55137-55-8,69980-43-4,69980-45-6,134309-86-7
(+)-α-hydroxymethyltyrosine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / Heating

2: pyridine / propan-2-ol / 3 h / Ambient temperature

3: 90 percent / NaOH / acetone / 3 h / Ambient temperature

5: 90 percent / HCl / 5 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; acetic anhydride; In isopropyl alcohol; acetone;
DOI:10.1007/BF01161067