CBZ-O-METHYL-L-SER

Base Information

• Chemical Name: CBZ-O-METHYL-L-SER
• CAS No.: 134807-65-1
• Molecular Formula: C12H15NO5
• Molecular Weight: 253.255
• Hs Code.: 2924299090
• Mol file: 134807-65-1.mol

Synonyms:CBZ-L-SERINE(METHYL ETHER);CBZ-O-METHYL-L-SER;CBZ-(S)-2-AMINO-3-METHOXYLPROPANOIC ACID

Chemical Property of CBZ-O-METHYL-L-SER

Chemical Property:

• PSA: 84.86000
• LogP: 1.40330

Purity/Quality:

98.5% ^*data from raw suppliers

CBZ-O-METHYL-L-SER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CBZ-O-METHYL-L-SER

There total 4 articles about CBZ-O-METHYL-L-SER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl N-[(benzyloxy)carbonyl]-O-methyl-L-serinate (84126-48-7) → (S)-2-(((benzyloxy)carbonyl)amino)-3-methoxypropanoic acid (134807-65-1)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 24h;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-(benzyloxycarbonyl)-L-serine (1145-80-8) → (S)-2-(((benzyloxy)carbonyl)amino)-3-methoxypropanoic acid (134807-65-1)

Guidance literature:

In diethyl ether; ethyl acetate;

Reference yield:

N-benzyloxycarbonyl-L-serine methyl ester (1676-81-9) → (S)-2-(((benzyloxy)carbonyl)amino)-3-methoxypropanoic acid (134807-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: silver(I) oxide / acetonitrile / 24 h / 20 °C / Inert atmosphere

2: lithium hydroxyde monohydrate; water monomer / methanol / Inert atmosphere

With lithium hydroxyde monohydrate; water monomer; silver(I) oxide; In methanol; acetonitrile;

DOI:10.1039/d2cc00167e

upstream raw materials:

diazomethane

N-(benzyloxycarbonyl)-L-serine

methyl N-[(benzyloxy)carbonyl]-O-methyl-L-serinate

N-benzyloxycarbonyl-L-serine methyl ester

Downstream raw materials:

C₁₅H₁₈N₄O₅

C₁₂H₁₆N₄O₃

C₁₂H₁₆INO₃

benzyl [(2R)-1-hydroxy-3-methoxypropan-2-yl]carbamate

Refernces

• 1、 -. "BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS". . . Retrieved 2016/10/24.