N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide

Base Information

• Chemical Name: N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide
• CAS No.: 134865-70-6
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• DSSTox Substance ID: DTXSID00424984
• Wikidata: Q82237733
• ChEMBL ID: CHEMBL1554246
• Mol file: 134865-70-6.mol

Synonyms:8-M-PDOT;134865-70-6;N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide;N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide;NCGC00024954-01;Tocris-1035;CHEMBL1554246;DTXSID00424984;E98671;J-006615

Chemical Property of N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide

Chemical Property:

• Vapor Pressure: 3.27E-08mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 447.8°Cat760mmHg
• Flash Point: 224.6°C
• PSA: 38.33000
• Density: 1.09g/cm³
• LogP: 2.46960
• Storage Temp.: Store at RT
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 233.141578849
• Heavy Atom Count: 17
• Complexity: 267

Purity/Quality:

98%min ^*data from raw suppliers

AH002 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC(=O)NC1CCC2=C(C1)C(=CC=C2)OC
• Isomeric SMILES: CCC(=O)N[C@@H]1CCC2=C(C1)C(=CC=C2)OC
• Description: 8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
• Uses: AH 002 is a selective melatonin receptor agonist.

Technology Process of N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide

There total 1 articles about N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

→ 8-Methoxy-(2R)-2-amino-1,2,3,4-tetrahydronaphthalene hydrochloride (3880-76-0) + 8-M-PDOT (134865-70-6,153811-19-9,153811-33-7)

Guidance literature:

Refernces