Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI)
• CAS No.: 135216-82-9
• Molecular Formula: C8H12N2
• Molecular Weight: 136.19428
• Mol file: 135216-82-9.mol

Synonyms:Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI)

Chemical Property of Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 1.90840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI)

There total 2 articles about Pyridazine, 3-methyl-5-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-chloro-4-isopropyl-6-methylpyridazine (135216-67-0) → 3-methyl-5-isopropylpyridazine (135216-82-9)

Guidance literature:

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; for 0.5h; under 2585.7 Torr; Ambient temperature;

Reference yield:

3-methylpyridazine (1632-76-4) + bis-(((isopropyl)sulfinyl)oxy)zinc → 4-isopropyl-3-methylpyridazine (1448776-97-3) + 3-methyl-5-isopropylpyridazine (135216-82-9)

Guidance literature:

With tert.-butylhydroperoxide; zinc sulfinate; bis(((trifluoromethyl)sulfinyl)oxy)zinc; In water; dimethyl sulfoxide; at 20 - 50 ℃; for 16h; Overall yield = 71 %; regioselective reaction;

DOI:10.1021/ja406223k

upstream raw materials:

3-chloro-4-isopropyl-6-methylpyridazine

3-methylpyridazine

Refernces

• 1、 Samaritoni, Jack G.,Babbitt, George. "Homolytic Alkylations of Substituted Pyridazines". . p. 583 - 587. Retrieved 2007/10/02.