3-Acetyl-3-hydroxyoxolan-2-one

Base Information

• Chemical Name: 3-Acetyl-3-hydroxyoxolan-2-one
• CAS No.: 135366-64-2
• Molecular Formula: C6H8O4
• Molecular Weight: 144.127
• DSSTox Substance ID: DTXSID10454156
• Nikkaji Number: J1.263.599K
• Mol file: 135366-64-2.mol

Synonyms:3-ACETYL-3-HYDROXYOXOLAN-2-ONE;135366-64-2;2(3H)-Furanone, 3-acetyldihydro-3-hydroxy- (9CI);3-Acetyl-3-hydroxyoxolane-2-one;SCHEMBL7517029;2-acetyl-2-hydroxy-butyrolactone;DTXSID10454156;EN300-384224;2(3H)-Furanone, 3-acetyldihydro-3-hydroxy-(9CI)

Chemical Property of 3-Acetyl-3-hydroxyoxolan-2-one

Chemical Property:

• PSA: 63.60000
• LogP: -0.74660
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 144.04225873
• Heavy Atom Count: 10
• Complexity: 186

Purity/Quality:

99% ^*data from raw suppliers

3-Acetyl-3-hydroxydihydrofuran-2(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1(CCOC1=O)O

Technology Process of 3-Acetyl-3-hydroxyoxolan-2-one

There total 2 articles about 3-Acetyl-3-hydroxyoxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → α-acetyl-α-hydroxy-γ-butyrolactone (135366-64-2)

Guidance literature:

With 3,3-dimethyldioxirane; nickel diacetate; In water; acetone; for 3.5h; Ambient temperature;

DOI:10.1016/0040-4020(96)00231-1

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → α-acetyl-α-hydroxy-γ-butyrolactone (135366-64-2) + 6-hydroxy-6-methyl-9-phenyl-2,7,8-trioxaspiro[4.5]decan-1-one + 3-acetyl-3-(2-oxo-2-phenylethyl)tetrahydro-2-pyranone

Guidance literature:

With oxygen; cerium(III) chloride; In isopropyl alcohol; at 23 ℃; for 16h;

DOI:10.1002/ejoc.200300439

Reference yield: 91.25%

α-acetyl-α-hydroxy-γ-butyrolactone (135366-64-2) → 3-chloro-3-acetylpropanol (13045-13-1)

Guidance literature:

With hydrogenchloride; In water; at 70 ℃; for 4h; under 3600.36 Torr; Temperature; Pressure; Green chemistry;

upstream raw materials:

3-acetyl-2-oxo-4,5-dihydrofuran

styrene

Downstream raw materials:

3-chloro-3-acetylpropanol

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