4-Amino-3,5-difluorobenzaldehyde

Base Information

Chemical Name:4-Amino-3,5-difluorobenzaldehyde
CAS No.:135564-23-7
Molecular Formula:C7H5F2NO
Molecular Weight:157.12
Hs Code.:
DSSTox Substance ID:DTXSID50598260
Wikidata:Q82493996
Mol file:135564-23-7.mol

Synonyms:4-Amino-3,5-difluorobenzaldehyde;135564-23-7;Benzaldehyde, 4-amino-3,5-difluoro- (9CI);SCHEMBL2541967;DTXSID50598260

Suppliers and Price of 4-Amino-3,5-difluorobenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
4-amino-3,5-difluorobenzaldehyde 95%+
1g
$ 2079.00

Chemcia Scientific
4-Amino-3,5-difluoro-benzaldehyde 95%
2.5 G
$ 1185.00

Total 7 raw suppliers

Chemical Property of 4-Amino-3,5-difluorobenzaldehyde

Chemical Property:

Boiling Point:235.0±40.0 °C(Predicted)
PKA:-0.92±0.10(Predicted)
PSA：43.09000
Density:1.405±0.06 g/cm3(Predicted)
LogP:1.94070
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:157.03392011
Heavy Atom Count:11
Complexity:141

Purity/Quality:

99% ^*data from raw suppliers

4-amino-3,5-difluorobenzaldehyde 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C(=C1F)N)F)C=O

Technology Process of 4-Amino-3,5-difluorobenzaldehyde

There total 1 articles about 4-Amino-3,5-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110301-23-0
4-amino-3,5-difluorobenzonitrile

: 135564-23-7
4-amino-3,5-difluorobenzaldehyde

Guidance literature:: 4-amino-3,5-difluorobenzonitrile; With diisobutylaluminium hydride; In toluene; at 0 - 20 ℃; for 2h;

With water; citric acid; In toluene;

Reference yield:

: 205180-05-8
cyclopentyl leucinate

: 135564-23-7
4-amino-3,5-difluorobenzaldehyde

: 956926-71-9
cyclopentyl 2(S)-[(4-amino-3,5-difluorobenzyl)amino]-4-methylpentanoate

Guidance literature:: cyclopentyl leucinate; 4-amino-3,5-difluorobenzaldehyde; With potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide; for 1h; pH=5 - 6;

With sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 205180-05-8
cyclopentyl leucinate

: 135564-23-7
4-amino-3,5-difluorobenzaldehyde

: 956926-69-5
cyclopentyl (S)-2-[(4-amino-3,5-difluorobenzyl)-tert-butoxycarbonylamino]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; acetic acid / methanol; N,N-dimethyl-formamide / 1 h / pH 5 - 6

1.2: 18 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran; water / 18 h / 20 °C

With potassium carbonate; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;