3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-

Base Information

Chemical Name:3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-
CAS No.:135574-22-0
Molecular Formula:C₂₁H₂₃NO₇
Molecular Weight:401.416
Hs Code.:
Mol file:135574-22-0.mol

Synonyms:3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-

Suppliers and Price of 3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-

Chemical Property:

Boiling Point:617.6±55.0 °C(Predicted)
PKA:13.51±0.40(Predicted)
PSA：86.69000
Density:1.38±0.1 g/cm3(Predicted)
LogP:2.94050

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy-

There total 7 articles about 3H-Oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-1,5,6,10b-tetrahydro-6-hydroxy-8,9-dimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135574-67-3
[(4S,5R)-4,5-Bis-(3,4-dimethoxy-phenyl)-2-oxo-oxazolidin-3-yl]-acetaldehyde

: 135574-21-9
(1R,10bS)-1-(3,4-Dimethoxy-phenyl)-8,9-dimethoxy-1,10b-dihydro-oxazolo[4,3-a]isoquinolin-3-one

: 135574-22-0
(1R,10bS)-1-(3,4-Dimethoxy-phenyl)-6-hydroxy-8,9-dimethoxy-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: With hydrogenchloride; In acetone; at 0 - 40 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)74327-9

Reference yield:

: 135574-20-8
(4S,5R)-3-(2,2-Dimethoxy-ethyl)-4,5-bis-(3,4-dimethoxy-phenyl)-oxazolidin-2-one

: 135574-21-9
(1R,10bS)-1-(3,4-Dimethoxy-phenyl)-8,9-dimethoxy-1,10b-dihydro-oxazolo[4,3-a]isoquinolin-3-one

: 135574-22-0
(1R,10bS)-1-(3,4-Dimethoxy-phenyl)-6-hydroxy-8,9-dimethoxy-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: With hydrogenchloride; In acetone; at 0 - 40 ℃; Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)74327-9

Reference yield:

: 135574-15-1,140687-74-7
(2R*,3R*)-2,3-bis(3,4-dimethoxyphenyl)oxirane

: 135574-22-0
(1R,10bS)-1-(3,4-Dimethoxy-phenyl)-6-hydroxy-8,9-dimethoxy-1,5,6,10b-tetrahydro-oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂; butan-1-ol / 2 h / r.t. to 140 deg C

2: 91 percent / NaOMe / toluene / 6 h / Heating

3: aq. HCl / acetone / 0 deg C to r.t.

4: aq. HCl / acetone / 0 - 40 °C

With hydrogenchloride; sodium methylate; In dichloromethane; acetone; toluene; butan-1-ol;
DOI:10.1016/S0040-4039(00)74327-9