Ethyl 5-bromoimidazo[1,2-A]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 5-bromoimidazo[1,2-A]pyridine-2-carboxylate
• CAS No.: 135995-46-9
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.098
• Hs Code.: 2933990090
• European Community (EC) Number: 968-345-8
• Mol file: 135995-46-9.mol

Synonyms:135995-46-9;ETHYL 5-BROMOIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;5-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl (5-bromoimidazo[1,2-a]pyridin-2-yl)acetate;MFCD06796255;SCHEMBL102137;ethyl 5-bromo-imidazo[1,2-a]pyridine-2-carboxylate;VJMNOJHFYDPFKP-UHFFFAOYSA-N;AKOS025293725;PB30863;AS-34342;SY039844;DB-063111;CS-0049444;EN300-7358873;Ethyl 5-bromoimidazo[1,2-a]pyridine-2-carboxylate, AldrichCPR

Chemical Property of Ethyl 5-bromoimidazo[1,2-A]pyridine-2-carboxylate

Chemical Property:

• PKA: 1.63±0.50(Predicted)
• PSA: 43.60000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 2.20240
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.98474
• Heavy Atom Count: 15
• Complexity: 250

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl5-Bromoimidazo[1,2-A]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2C(=N1)C=CC=C2Br

Technology Process of Ethyl 5-bromoimidazo[1,2-A]pyridine-2-carboxylate

There total 2 articles about Ethyl 5-bromoimidazo[1,2-A]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ ethyl 5-bromoimidazo[1,2-a]pyridine-2-carboxylate (135995-46-9)

Guidance literature:

Reference yield: 64.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + ethyl Bromopyruvate (70-23-5) → ethyl 5-bromoimidazo[1,2-a]pyridine-2-carboxylate (135995-46-9)

Guidance literature:

In ethanol; Reflux;

Reference yield: 95.0%

ethyl 5-bromoimidazo[1,2-a]pyridine-2-carboxylate (135995-46-9) + phenylboronic acid (98-80-6) → ethyl 5-phenyl-imidazo[1,2-a]pyridine-2-carboxylate (872363-06-9)

Guidance literature:

With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; toluene; at 20 - 80 ℃; for 12h;

upstream raw materials:

2-Amino-6-bromopyridine

ethyl Bromopyruvate

Downstream raw materials:

ethyl 5-phenyl-imidazo[1,2-a]pyridine-2-carboxylate

(5-bromoimidazo[1,2-a]pyridin-2-yl)methanol

5-bromoimidazo[1,2-a]pyridine-2-carboxylic acid

5-bromoimidazo[1,2-a]pyridin-2-ylaminocarboxylic acid tert-butyl ester

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