NITRAZEPAM-D5

Base Information

• Chemical Name: NITRAZEPAM-D5
• CAS No.: 136765-45-2
• Molecular Formula: C15H6D5N3O3
• Molecular Weight: 286.3
• Mol file: 136765-45-2.mol

Synonyms:NITRAZEPAM-D5;7-Nitro-5-(phenyl-d5)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;1,3-Dihydro-7-nitro-5-(phenyl-d5)-2H-1,4-benzodiazepin-2-one;Benzalin-d5;Calsmin-d5;Eatan-d5;Eunoctin-d5;Mogadon-d5

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of NITRAZEPAM-D5

Chemical Property:

• Melting Point: 224-2260C
• Flash Point: 2℃
• PSA: 87.28000
• LogP: 2.48110
• Storage Temp.: Controlled Substance, -20°C Freezer

Purity/Quality:

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Description: Nitrazepam-d5 is intended for use as an internal standard for the quantification of nitrazepam by GC-or LC-MS. Nitrazepam is a benzodiazepine compound that acts as an agonist at the GABAA receptor to produce anxiolytic and hypnotic effects. This product is intended for forensic and research applications.
• Uses: Nitrazepam-d5, is the labeled analogue of Nitrazepam (N490140), which is an anticonvulsant, and hypnotic. Controlled substance (depressant).

Technology Process of NITRAZEPAM-D5

There total 3 articles about NITRAZEPAM-D5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C15H7(2)H4ClN2O4 → C15H6(2)H5N3O3 (136765-45-2)

Guidance literature:

With hexamethylenetetramine; ammonium chloride; In methanol; for 24h; Inert atmosphere; Reflux;

Reference yield:

2,3,4,5,6-pentadeuteriumbenzeneboronic acid (215527-70-1) → C15H6(2)H5N3O3 (136765-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,4'-dimethyl-2,2'-bipyridines / tetrahydrofuran; water / 24 h / 90 °C

2: 12 h / 20 °C / Inert atmosphere

3: ammonium chloride; hexamethylenetetramine / methanol / 24 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,4'-dimethyl-2,2'-bipyridines; hexamethylenetetramine; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; water;

Reference yield:

5-nitroanthranilonitrile (17420-30-3) → C15H6(2)H5N3O3 (136765-45-2)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,4'-dimethyl-2,2'-bipyridines / tetrahydrofuran; water / 24 h / 90 °C

2: 12 h / 20 °C / Inert atmosphere

3: ammonium chloride; hexamethylenetetramine / methanol / 24 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4,4'-dimethyl-2,2'-bipyridines; hexamethylenetetramine; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; water;

upstream raw materials:

2,3,4,5,6-pentadeuteriumbenzeneboronic acid

5-nitroanthranilonitrile