3-(Pyridin-2-yloxy)benzaldehyde

Base Information

• Chemical Name: 3-(Pyridin-2-yloxy)benzaldehyde
• CAS No.: 137386-78-8
• Molecular Formula: C12H9NO2
• Molecular Weight: 199.209
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00370694
• Wikidata: Q82157828
• Mol file: 137386-78-8.mol

Synonyms:3-(Pyridin-2-yloxy)benzaldehyde;137386-78-8;3-(Pyrid-2-yloxy)benzaldehyde;3-pyridin-2-yloxybenzaldehyde;3-(2-Pyridinyloxy)benzaldehyde;Benzaldehyde, 3-(2-pyridinyloxy)-;3-(2-Pyridinyloxy)-benzaldehyde;SCHEMBL2349067;DTXSID00370694;YGXYNKLOBXMTGL-UHFFFAOYSA-N;3-[(Pyridin-2-yl)oxy]benzaldehyde;AR1595;MFCD03840110;AKOS006230747;PS-3614;SB52932;3-(pyrid-2-yloxy)benzaldehyde, AldrichCPR;CS-0074844;FT-0691935;EN300-239654;A926248;Z54631506;F9995-2422

Chemical Property of 3-(Pyridin-2-yloxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 1.88E-05mmHg at 25°C
• Refractive Index: 1.614
• Boiling Point: 362.8°Cat760mmHg
• Flash Point: 173.2°C
• PSA: 39.19000
• Density: 1.207g/cm³
• LogP: 2.68640
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.063328530
• Heavy Atom Count: 15
• Complexity: 208

Purity/Quality:

98%min ^*data from raw suppliers

3-(Pyridin-2-yloxy)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)OC2=CC=CC(=C2)C=O

Technology Process of 3-(Pyridin-2-yloxy)benzaldehyde

There total 8 articles about 3-(Pyridin-2-yloxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C15H15NO3 → 3-(pyridin-2-yloxy)benzaldehyde (137386-78-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1016/j.ejmech.2021.113784

Reference yield: 73.0%

2-bromo-pyridine (109-04-6) + meta-hydroxybenzaldehyde (100-83-4) → 3-(pyridin-2-yloxy)benzaldehyde (137386-78-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 170 ℃; for 3h;

DOI:10.1039/d1md00175b

Reference yield: 61.0%

2-bromo-pyridine (109-04-6) + 3-Hydroxybenzyl alcohol (620-24-6) → 3-(pyridin-2-yloxy)benzaldehyde (137386-78-8)

Guidance literature:

2-bromo-pyridine; 3-Hydroxybenzyl alcohol; With pyridine; potassium carbonate; at 90 ℃; for 0.166667h;

copper(II) oxide; for 48h; Heating / reflux;

upstream raw materials:

2-bromo-pyridine

3-Hydroxybenzyl alcohol

meta-hydroxybenzaldehyde

N,N-Dimethylhydrazine

Refernces

• 1、 Chen, Hekai,Kong, Jun,Li, Tian,Xu, Qun,Yin, Hang,Zhang, Liwei. "Design and optimisation of a small-molecule TLR2/4 antagonist for anti-tumour therapy". supporting information. p. 1771 - 1779. Retrieved 2021/11/19.
• 2、 -. "RECEPTOR FUNCTION REGULATING AGENT". Page/Page column 91. . Retrieved 2010/11/23.