3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI)
• CAS No.: 137522-54-4
• Molecular Formula: C8H9N3O3
• Molecular Weight: 195.17536
• Mol file: 137522-54-4.mol

Synonyms:3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI)

Chemical Property of 3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI)

Chemical Property:

• PSA: 120.29000
• LogP: 1.23470

Purity/Quality:

3-PYRIDINECARBOXYLIC ACID, 6-AMINO-5-(AMINOCARBONYL)-2-METHYL- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI)

There total 2 articles about 3-Pyridinecarboxylicacid,6-amino-5-(aminocarbonyl)-2-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

6-amino-5-cyano-2-methylnicotinic acid ethyl ester (137522-47-5) → amide of 2-amino-5-carboxy-6-methylnicotinic acid (137522-54-4)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

DOI:10.1007/BF00768980

Reference yield:

ethyl 6-chloro-5-cyano-2-methylnicotinate (64119-42-2) → amide of 2-amino-5-carboxy-6-methylnicotinic acid (137522-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / ammonia / ethanol / Heating

2: 67 percent / KOH / ethanol / Heating

With potassium hydroxide; ammonia; In ethanol;

DOI:10.1007/BF00768980

Reference yield: 22.0%

amide of 2-amino-5-carboxy-6-methylnicotinic acid (137522-54-4) → 2-amino-6-methylnicotinamide (100524-09-2)

Guidance literature:

at 260 ℃; for 0.166667h;

DOI:10.1007/BF00768980

upstream raw materials:

6-amino-5-cyano-2-methylnicotinic acid ethyl ester

ethyl 6-chloro-5-cyano-2-methylnicotinate

Downstream raw materials:

2-amino-6-methylnicotinamide

Sodium; 6-amino-5-carbamoyl-2-methyl-nicotinate