5-Bromobufuralol Hydrochloride

Base Information

• Chemical Name: 5-Bromobufuralol Hydrochloride
• CAS No.: 137740-36-4
• Molecular Formula: C16H22BrNO2HCl
• Molecular Weight: 376.721
• Mol file: 137740-36-4.mol

Synonyms:5-Bromo-.alpha.-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol, hydrochloride;5-Bromo-.α.-[[(1,1-dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol, hydrochloride

Chemical Property of 5-Bromobufuralol Hydrochloride

Chemical Property:

• PSA: 45.40000
• LogP: 5.37210

Purity/Quality:

97% ^*data from raw suppliers

5-BromobufuralolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the synthesiis of Bufuralol, a -Adrenergic blocker with peripheral vasodilating activity

Technology Process of 5-Bromobufuralol Hydrochloride

There total 14 articles about 5-Bromobufuralol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-ethylphenol (18980-21-7) → 1-(5-Bromo-7-ethyl-benzofuran-2-yl)-2-tert-butylamino-ethanol; hydrochloride (137740-36-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 61 percent / hexamethylenetetramine, glacial acetic acid, sulfuric acid / 18 h / 25 °C

2: 80 percent / potassium carbonate, N, N-dimethylformamide / 1.5 h / Heating

3: 49 percent / trifluoroacetic acid / 0.25 h / Heating

4: 1) sodium methylsulfinylmethide / 1) dimethyl sulfoxide, tetrahydrofuran, 0 deg C, 2 min, 2) tetrahydrofuran, 0 deg C, 30 min, then 24 deg C, 1 h

5: hexane; methanol / 14 h / Heating

6: hydrochloric acid / ethanol

With hydrogenchloride; hexamethylenetetramine; sulfuric acid; dimsylsodium; potassium carbonate; acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid; In methanol; ethanol; hexane;

DOI:10.1002/jhet.5570280535

Reference yield:

5-bromo-2-(2-tert-butylamino-1-hydroxyethyl)-7-ethylbenzofuran (85536-86-3) → 1-(5-Bromo-7-ethyl-benzofuran-2-yl)-2-tert-butylamino-ethanol; hydrochloride (137740-36-4)

Guidance literature:

With hydrogenchloride; In ethanol; Yield given;

DOI:10.1002/jhet.5570280535

Reference yield:

5-bromo-7-ethyl-2-(1,2-epoxyethyl)benzofuran (69543-78-8) → 1-(5-Bromo-7-ethyl-benzofuran-2-yl)-2-tert-butylamino-ethanol; hydrochloride (137740-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hexane; methanol / 14 h / Heating

2: hydrochloric acid / ethanol

With hydrogenchloride; In methanol; ethanol; hexane;

DOI:10.1002/jhet.5570280535

upstream raw materials:

5-bromo-2-(2-tert-butylamino-1-hydroxyethyl)-7-ethylbenzofuran

5-bromo-7-ethyl-2-(1,2-epoxyethyl)benzofuran

5-bromo-3-ethylsalicylaldehyde

4-bromo-2-ethylphenol

Downstream raw materials:

Bufuralol hydrochloride