4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID

Base Information

• Chemical Name: 4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID
• CAS No.: 138385-00-9
• Molecular Formula: C16H22N2O6S
• Molecular Weight: 370.426
• Hs Code.: 2935009090
• Mol file: 138385-00-9.mol

Synonyms:4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID;BUTTPARK 120\07-07

Chemical Property of 4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID

Chemical Property:

• PSA: 112.60000
• LogP: 2.58280

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Boc-piperazin-1-ylsulfonyl)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID

There total 5 articles about 4-((4-(TERT-BUTOXYCARBONYL)PIPERAZINYL)SULFONYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

p-carboxyphenylsulfonyl chloride (10130-89-9) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(4-carboxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (138385-00-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h;

DOI:10.1021/jm00082a006

Reference yield:

methyl 4-<<4-(tert-butoxycarbonyl)piperazinyl>sulfonyl>benzoate (138384-97-1) → 4-(4-carboxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (138385-00-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(4-carboxy-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (138385-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h

2: lithium hydroxide / methanol; tetrahydrofuran; water / 4 h

With triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2021.116242

upstream raw materials:

p-carboxyphenylsulfonyl chloride

1-t-Butoxycarbonylpiperazine

methyl 4-<<4-(tert-butoxycarbonyl)piperazinyl>sulfonyl>benzoate

4-chlorosulfonyl-benzoic acid methyl ester

Downstream raw materials:

4-[4-(cyanomethylcarbamoyl)benzenesulfonyl]piperazine-1-carboxylic acid tert-butyl ester

4-(4-{[Isopropyl-(2-oxo-1,2-dihydro-benzo[cd]indol-6-yl)-amino]-methyl}-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester

N⁶-ethyl-N⁶-<4-<<4-(tert-butoxycarbonyl)piperazinyl>sulfonyl>benzyl>-6-aminobenzindol-2(1H)-one

6-{(3-Hydroxy-propyl)-[4-(piperazine-1-sulfonyl)-benzyl]-amino}-1H-benzo[cd]indol-2-one

Refernces

• 1、 -. "VACCINE ADJUVANT". Page/Page column 82. . Retrieved 2020/06/10.
• 2、 -. "BENZAMIDINE DERIVATIVES". . . Retrieved 2008/06/13.