(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol

Base Information

• Chemical Name: (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol
• CAS No.: 138745-99-0
• Molecular Formula: C9H8N2OS
• Molecular Weight: 192.24
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10406897
• Wikidata: Q82212036
• Mol file: 138745-99-0.mol

Synonyms:(2-pyridin-3-yl-1,3-thiazol-4-yl)methanol;138745-99-0;4-Thiazolemethanol, 2-(3-pyridinyl)-;(2-(3-pyridyl)-4-thiazolyl)methanol;[2-(pyridin-3-yl)-1,3-thiazol-4-yl]methanol;SCHEMBL2434206;DTXSID10406897;CHEBI:195074;FDSDADPVFPJLAN-UHFFFAOYSA-N;2-(3-pyridyl)-4-thiazolylmethanol;MFCD07368503;AKOS006283005;(2-(pyridin-3-yl)thiazol-4-yl)methanol;FT-0690312;[2-(3-pyridinyl)-1,3-thiazol-4-yl]methanol;W-205519;(2-pyridin-3-yl-1,3-thiazol-4-yl)methanol, AldrichCPR

Chemical Property of (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol

Chemical Property:

• Vapor Pressure: 2.26E-07mmHg at 25°C
• Melting Point: 120 °C
• Refractive Index: 1.637
• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 200.3°C
• PSA: 74.25000
• Density: 1.33g/cm³
• LogP: 1.69740
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 192.03573406
• Heavy Atom Count: 13
• Complexity: 168

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

(2-PYRIDIN-3-YL-1,3-THIAZOL-4-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CN=C1)C2=NC(=CS2)CO
• Uses: 2-(3-Pyridinyl)-4-thiazolemethanol is an intermediate in the preparation of imidazothiadiazole and imidazopyridazine derivatives and analogs as PAR4 antagonists useful as selective platelet aggregation inhibitors.

Technology Process of (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol

There total 3 articles about (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-(pyridin-3-yl)thiazole-4-carbaldehyde (184679-13-8) → (2-(pyridin-3-yl)-4-thiazolyl)methanol (138745-99-0)

Guidance literature:

2-(pyridin-3-yl)thiazole-4-carbaldehyde; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 25 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; methanol;

Reference yield: 30.0%

ethyl 2-(pyridin-3-yl) thiazole-4-carboxylate (39067-28-2) → (2-(pyridin-3-yl)-4-thiazolyl)methanol (138745-99-0)

Guidance literature:

Reference yield: 16.0%

→ (2-(pyridin-3-yl)-4-thiazolyl)methanol (138745-99-0)

Guidance literature:

upstream raw materials:

2-(pyridin-3-yl)thiazole-4-carbaldehyde

ethyl 2-(pyridin-3-yl) thiazole-4-carboxylate