8-Fluoroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 8-Fluoroimidazo[1,2-a]pyridine
• CAS No.: 139022-26-7
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.1264032
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL206692
• DSSTox Substance ID: DTXSID30461842
• Mol file: 139022-26-7.mol

Synonyms:8-fluoroimidazo(1,2-a)pyridine

Chemical Property of 8-Fluoroimidazo[1,2-a]pyridine

Chemical Property:

• Refractive Index: 1.603
• PSA: 17.30000
• Density: 1.27g/cm³
• LogP: 1.47340
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 136.04367633
• Heavy Atom Count: 10
• Complexity: 129

Purity/Quality:

97% ^*data from raw suppliers

8-Fluoroimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C(=C1)F

Technology Process of 8-Fluoroimidazo[1,2-a]pyridine

There total 4 articles about 8-Fluoroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzhydrylidene(3-fluoropyridin-2-yl)amine (628322-77-0) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 8-fluoroimidazo[1,2-a]pyridine (139022-26-7)

Guidance literature:

benzhydrylidene(3-fluoropyridin-2-yl)amine; Bromoacetaldehyde diethyl acetal; With hydrogen bromide; In water; at 90 ℃; for 0.333333h;

With sodium hydrogencarbonate; In water; isopropyl alcohol; at 50 ℃; for 18h;

Reference yield:

benzhydrylidene(3-fluoropyridin-2-yl)amine (628322-77-0) → 8-fluoroimidazo[1,2-a]pyridine (139022-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HBr / 90 °C

2: ethanol / Heating

With hydrogen bromide; In ethanol;

DOI:10.1016/j.bmcl.2005.12.037

Reference yield:

2-chloro-3-fluoropyridine (17282-04-1) → 8-fluoroimidazo[1,2-a]pyridine (139022-26-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Cs₂CO₃; BINAP; Pd(OAc)2 / toluene / 95 °C

2: aq. HBr / 90 °C

3: ethanol / Heating

With palladium diacetate; hydrogen bromide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; toluene;

DOI:10.1016/j.bmcl.2005.12.037

upstream raw materials:

3-fluoropyridin-2-amine

bromoacetaldehyde

benzhydrylidene(3-fluoropyridin-2-yl)amine

2-chloro-3-fluoropyridine

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