4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI)

Base Information

• Chemical Name: 4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI)
• CAS No.: 139240-76-9
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.16256
• Mol file: 139240-76-9.mol

Synonyms:4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI)

Chemical Property of 4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 0.99810

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI)

There total 9 articles about 4,7-Methanobenzoxazol-2(3H)-one,3a,4,7,7a-tetrahydro-,[3aR-(3a-alpha-,4-alpha-,7-alpha-,7a-alpha-)]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1R,2S,6R,7S)-5-{(1S,4R)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-ylcarbonyl}-3-oxa-5-azatricyclo[5.2.1.02,6]dec-8-en-4-one → (-)-(1R,2S,6R,7S)-3-oxa-5-azatricyclo[5.2.1.02,6]dec-8-en-4-one (139240-76-9)

Guidance literature:

With methanol; lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/ejoc.200600226

Reference yield:

3-acetyl-(3ac,7ac)-3a,4,7,7a-tetrahydro-3H-4r,7c-methano-benzooxazol-2-one (65929-62-6) → (+/-)-3-oxa-5-azatricyclo[5.2.1.02,6]dec-8-en-4-one (65929-64-8,139240-75-8,139240-76-9)

Guidance literature:

With sodium methylate; In methanol; for 4h; Heating;

Reference yield:

(+/-)-3-oxa-5-azatricyclo[5.2.1.02,6]dec-8-en-4-one (65929-64-8,139240-75-8,139240-76-9) → (-)-(1R,2S,6R,7S)-3-oxa-5-azatricyclo[5.2.1.02,6]dec-8-en-4-one (139240-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

1.2: tetrahydrofuran / 20 °C

2.1: 84 percent / lithium borohydride; methanol / tetrahydrofuran / 0 - 20 °C

With methanol; lithium borohydride; sodium hydride; In tetrahydrofuran;

DOI:10.1002/ejoc.200600226

upstream raw materials:

3-acetyl-(3ac,7ac)-3a,4,7,7a-tetrahydro-3H-4r,7c-methano-benzooxazol-2-one

cyclopenta-1,3-diene

(1R,2S,6R,7S)-5-((1S,2R,4R)-2-Methoxy-7,7-dimethyl-bicyclo[2.2.1]heptane-1-carbonyl)-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-one

(1R,2S,6R,7S)-5-((1S,2R,4R)-7,7-Dimethyl-2-propoxy-bicyclo[2.2.1]heptane-1-carbonyl)-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-one

Downstream raw materials:

(+)-(1S,2R,6S,7R)-3-oxa-5-azatricyclo[5.2.1.0^2,6]dec-8-en-4-one

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