Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI)

Base Information

• Chemical Name: Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI)
• CAS No.: 139484-26-7
• Molecular Formula: C9H9 N O
• Molecular Weight: 147.177
• Mol file: 139484-26-7.mol

Synonyms:Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI)

Chemical Property of Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI)

Chemical Property:

• PSA: 25.42000
• LogP: 1.46770

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI)

There total 6 articles about Oxireno[f]isoquinoline,1a,2,3,7b-tetrahydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

trans-5-acetoxy-6-bromo-5,6,7,8-tetrahydroisoquinoline (139484-25-6) → 5,6-epoxy-5,6,7,8-tetrahydroisoquinoline (139484-26-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; for 4h; Ambient temperature;

Reference yield:

5,6,7,8-tetrahydroisoquinoline (36556-06-6) → 5,6-epoxy-5,6,7,8-tetrahydroisoquinoline (139484-26-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 63 percent / H₂O₂, AcOH / 20 h / 90 °C

2: 58 percent / 3 h / Heating

3: 72 percent / 10percent HCl / Heating

4: 51 percent / polyphosphoric acid / 0.67 h / 90 - 100 °C

5: N-bromoacetamide, AcOH / 3 h / Ambient temperature

6: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature

With hydrogenchloride; PPA; dihydrogen peroxide; sodium methylate; acetic acid; N-bromoacetamide; In tetrahydrofuran;

Reference yield:

7,8-dihydroisoquinoline (24334-24-5) → 5,6-epoxy-5,6,7,8-tetrahydroisoquinoline (139484-26-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromoacetamide, AcOH / 3 h / Ambient temperature

2: 79 percent / MeONa / tetrahydrofuran / 4 h / Ambient temperature

With sodium methylate; acetic acid; N-bromoacetamide; In tetrahydrofuran;

upstream raw materials:

trans-5-acetoxy-6-bromo-5,6,7,8-tetrahydroisoquinoline

5,6,7,8-tetrahydroisoquinoline

7,8-dihydroisoquinoline

5,6,7,8-tetrahydroisoquinoline N-oxide

Downstream raw materials:

5,6-epoxy-5,6-dihydroisoquinoline

trans-5,6-dihydroisoquinoline-5,6-diol

5-hydroxyisoquinoline

8-bromo-5,6-epoxy-5,6,7,8-tetrahydroisoquinoline

Refernces