Technology Process of 2-Pyrrolidinone,3-amino-1-hydroxy-4-(1-methylethyl)-,cis-(9CI)
There total 10 articles about 2-Pyrrolidinone,3-amino-1-hydroxy-4-(1-methylethyl)-,cis-(9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) triethylamine, 2) titanium tetrachloride / 1) CH2Cl2, -78 deg C, 20 min, 2) CH2Cl2, -78 deg C, 1.5 h, then r.t. for 30 min
2: triethylamine, molecular sieves (3 Angstroem) / tetrahydrofuran / 6 h / 60 °C
3: 1) sodium cyanoborohydride, 1 M aq. HCl, 2) sodium methoxide / 1) MeOH, r.t., 2) MeOH, r.t., 4 h
4: 1) trifluoroacetic acid, 2) hydrogen / 2) palladium black / 1) r.t., 10 min, 2) EtOH, 50 psi, 2 h
With
hydrogenchloride; 3 A molecular sieve; hydrogen; sodium methylate; titanium tetrachloride; sodium cyanoborohydride; triethylamine; trifluoroacetic acid;
palladium;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)88493-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) triethylamine, 2) titanium tetrachloride / 1) CH2Cl2, -78 deg C, 20 min, 2) CH2Cl2, -78 deg C, 1.5 h, then r.t. for 30 min
2: triethylamine, molecular sieves (3 Angstroem) / tetrahydrofuran / 6 h / 60 °C
3: 1) sodium cyanoborohydride, 1 M aq. HCl, 2) sodium methoxide / 1) MeOH, r.t., 2) MeOH, r.t., 4 h
4: 1) trifluoroacetic acid, 2) hydrogen / 2) palladium black / 1) r.t., 10 min, 2) EtOH, 50 psi, 2 h
With
hydrogenchloride; 3 A molecular sieve; hydrogen; sodium methylate; titanium tetrachloride; sodium cyanoborohydride; triethylamine; trifluoroacetic acid;
palladium;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)88493-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine, molecular sieves (3 Angstroem) / tetrahydrofuran / 6 h / 60 °C
2: 1) sodium cyanoborohydride, 1 M aq. HCl, 2) sodium methoxide / 1) MeOH, r.t., 2) MeOH, r.t., 4 h
3: 1) trifluoroacetic acid, 2) hydrogen / 2) palladium black / 1) r.t., 10 min, 2) EtOH, 50 psi, 2 h
With
hydrogenchloride; 3 A molecular sieve; hydrogen; sodium methylate; sodium cyanoborohydride; triethylamine; trifluoroacetic acid;
palladium;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)88493-3