N-tert-butyl-2-methylpropanamide

Base Information

• Chemical Name: N-tert-butyl-2-methylpropanamide
• CAS No.: 7472-49-3
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Mol file: 7472-49-3.mol

Synonyms:Propionamide,N-tert-butyl-2-methyl- (6CI,7CI,8CI); N-Isobutyryl-tert-butylamine; NSC 402039

Chemical Property of N-tert-butyl-2-methylpropanamide

Chemical Property:

• Vapor Pressure: 0.16mmHg at 25°C
• Boiling Point: 213.9°C at 760 mmHg
• Flash Point: 115.8°C
• Density: 0.857g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-tert-butyl-2-methylpropanamide

There total 4 articles about N-tert-butyl-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

t-butylnitrite (917-95-3) + 2-methyl-1-(trimethylsilyl)prop-1-enyl triflate (73876-87-6) → 2,2,4,4-tetramethyl-1,3-cyclobutanedione (933-52-8) + dimethylacetylene (503-17-3) + 2-Methyl-2-nitropropane (594-70-7) + N-tert-butylmethacrylamide (6554-73-0) + N-tert-butylisobutyramide (7472-49-3) + N-tert-butyl-2-hydroxy-2-methylpropanamide (13947-81-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In 1,2-dimethoxyethane; at -20 ℃; for 0.0333333h; Mechanism;

Reference yield: 21.2%

1,4-diisobutanoylpiperazine-2,5-dione → Glycine anhydride (106-57-0) + N-tert-butylisobutyramide (7472-49-3) + 1-isobutyryl-2,5-piperazinedione (151079-68-4)

Guidance literature:

With tert-butylamine; In acetonitrile; at 0 ℃; for 60h; Irradiation;

DOI:10.3987/COM-92-6265

Reference yield:

2-bromo-N-(tert-butyl)-2-methylpropanamide (66875-78-3) → N-tert-butylmethacrylamide (6554-73-0) + N-tert-butylisobutyramide (7472-49-3) + tert-butylisonitrile (119072-55-8,7188-38-7)

Guidance literature:

With tetraethylammonium perchlorate; In acetonitrile; Yield given. Yields of byproduct given; electrochemical reduction at -1.4 V;

upstream raw materials:

dimethylketene

bis(tert-butyl)sulfur diimide

2-bromo-N-(tert-butyl)-2-methylpropanamide

t-butylnitrite

Refernces

• 1、 Sera, Akira,Okada, Manabu,Ohhata, Akira,Yamada, Hiroaki,Itoh, Kuniaki,Kubo, Yasuo. "NORRISH TYPE II PHOTO-DEACYLATION OF SEMICYCLIC IMIDES". . p. 1039 - 1046. Retrieved 2007/10/02.