Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)
CAS No.:139689-84-2
Molecular Formula:C8H14O3S
Molecular Weight:190.25996
Hs Code.:
Mol file:139689-84-2.mol

Synonyms:Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)

Suppliers and Price of Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)

Chemical Property:

PSA：62.75000
LogP:1.27120

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI)

There total 2 articles about Bicyclo[2.2.1]heptan-2-ol, 6-(methylsulfonyl)-, (2-exo,6-endo)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 139689-86-4
tert-Butyl-((1S,2S,4R,6S)-6-methanesulfonyl-bicyclo[2.2.1]hept-2-yloxy)-dimethyl-silane

: 2-exo-hydroxybicyclo<2.2.1>heptane-6-endo-thiol

: 139757-85-0
(1R,2R,4S,6R)-6-Methylsulfanyl-bicyclo[2.2.1]heptan-2-ol

: 139689-84-2
(1R,2R,4S,6R)-6-Methanesulfonyl-bicyclo[2.2.1]heptan-2-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; benzene; at 90 ℃; for 72h;
DOI:10.1021/jo00035a026

Reference yield:

: 139689-82-0
5-endo-(methylsulfonyl)-2-norbornene

: 139689-89-7
(1R,2S,4R,5R)-5-Methanesulfonyl-bicyclo[2.2.1]heptan-2-ol

: 139689-84-2
(1R,2R,4S,6R)-6-Methanesulfonyl-bicyclo[2.2.1]heptan-2-ol

Guidance literature:: With dihydrogen peroxide; diborane; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, r.t., 48 h, 2) overnight;
DOI:10.1021/jo00035a026

Reference yield:

: 139689-84-2
(1R,2R,4S,6R)-6-Methanesulfonyl-bicyclo[2.2.1]heptan-2-ol

: 139689-80-8
Cyclohexyl-((1S,2R,4R,6S)-6-methylsulfanyl-bicyclo[2.2.1]hept-2-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / imidazole / dimethylformamide / 40 °C

2: DIBALH / benzene; toluene / 72 h / 90 °C

3: 1) DMSO, oxalyl chloride, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 15 min, 2) r.t.

4: 92 percent / molecular sieves 3A / 120 - 130 °C

5: DIBALH / benzene; toluene / 80 °C

With 1H-imidazole; oxalyl dichloride; 3 A molecular sieve; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo00035a026