Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)
CAS No.:139757-83-8
Molecular Formula:C9H15NO2S
Molecular Weight:201.2859
Hs Code.:
Mol file:139757-83-8.mol

Synonyms:Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)

Suppliers and Price of Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)

Chemical Property:

PSA：88.62000
LogP:1.63030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI)

There total 6 articles about Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-amino-6-(methylthio)-, (endo,endo)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 139689-93-3
C₁₀H₁₄N₂O₂S

: 139757-83-8,160798-12-9,609844-47-5
(+/-)-2-endo-amino-6-endo-(methylthio)bicyclo<2.2.1>heptane-2-exo-carboxylic acid

Guidance literature:: With barium dihydroxide; In water; at 120 ℃;
DOI:10.1021/jo00035a026

Reference yield:

: 139689-82-0
5-endo-(methylsulfonyl)-2-norbornene

: 139757-83-8,160798-12-9,609844-47-5
(+/-)-2-endo-amino-6-endo-(methylthio)bicyclo<2.2.1>heptane-2-exo-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1) B₂H₆, 2) 30percent aq. H₂O₂ / 1) THF, r.t., 48 h, 2) overnight

2: 93 percent / imidazole / dimethylformamide / 40 °C

3: DIBALH / benzene; toluene / 72 h / 90 °C

4: 1) DMSO, oxalyl chloride, 2) Et₃N / 1) CH₂Cl₂, -78 deg C, 15 min, 2) r.t.

5: 60 percent / (NH₄)2CO₃ / H₂O; methanol / 48 h / 80 °C

6: 85 percent / Ba(OH)2 / H₂O / 120 °C

With 1H-imidazole; barium dihydroxide; oxalyl dichloride; dihydrogen peroxide; ammonium carbonate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; diborane; In methanol; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jo00035a026

Reference yield:

: 139689-76-2
6-endo-(methylthio)bicyclo[2.2.1]heptan-2-one

: 139757-83-8,160798-12-9,609844-47-5
(+/-)-2-endo-amino-6-endo-(methylthio)bicyclo<2.2.1>heptane-2-exo-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / (NH₄)2CO₃ / H₂O; methanol / 48 h / 80 °C

2: 85 percent / Ba(OH)2 / H₂O / 120 °C

With barium dihydroxide; ammonium carbonate; In methanol; water;
DOI:10.1021/jo00035a026