2-Quinolinamine,5,6,7,8-tetrahydro-(9CI)

Base Information

• Chemical Name: 2-Quinolinamine,5,6,7,8-tetrahydro-(9CI)
• CAS No.: 139908-32-0
• Molecular Formula: C₉H₁₂N₂
• Molecular Weight: 148.208
• Mol file: 139908-32-0.mol

Synonyms:2-Amino-5,6,7,8-tetrahydroquinoline

Chemical Property of 2-Quinolinamine,5,6,7,8-tetrahydro-(9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99%min ^*data from raw suppliers

5,6,7,8-tetrahydroquinolin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Quinolinamine,5,6,7,8-tetrahydro-(9CI)

There total 4 articles about 2-Quinolinamine,5,6,7,8-tetrahydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide (477531-98-9) → 2-Amino-5,6,7,8-tetrahydroquinoline (139908-32-0)

Guidance literature:

With sodium hydroxide; In HCl [hydrochloric acid];

Reference yield:

cyclohexanone-2-propionitrile (4594-78-9) → 2-Amino-5,6,7,8-tetrahydroquinoline (139908-32-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. hydroxylammonium sulfate, aq. NaOH / diethyl ether / 16 h

2: 36 percent Chromat_. / acetyl chloride (AcCl) / 4 h / 100 - 130 °C

3: aq. NaOH / 2 h / Heating

With sodium hydroxide; hydroxyammonium sulfate; acetyl chloride; In diethyl ether;

DOI:10.1021/jo00056a021

Reference yield:

2-(N-Acetylamino)-5,6,7,8-tetrahydroquinoline (146331-18-2) → 2-Amino-5,6,7,8-tetrahydroquinoline (139908-32-0)

Guidance literature:

With sodium hydroxide; for 2h; Yield given; Heating;

DOI:10.1021/jo00056a021

upstream raw materials:

2-(N-Acetylamino)-5,6,7,8-tetrahydroquinoline

cyclohexanone-2-propionitrile

2-(2-Cyanoethyl)cyclohexanone oxime

N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide

Refernces

• 1、 -. "Synthesis of enantiomerically pure amino-substituted fused bicyclic rings". . . Retrieved 2008/06/13.