(S)-Fexofenadine

Base Information

Chemical Name:(S)-Fexofenadine
CAS No.:139965-11-0
Molecular Formula:C₃₂H₃₉NO₄
Molecular Weight:501.666
Hs Code.:
DSSTox Substance ID:DTXSID901039730
Nikkaji Number:J434.877J
ChEMBL ID:CHEMBL68381
Mol file:139965-11-0.mol

Synonyms:(S)-Fexofenadine;139965-11-0;S-FEXOFENADINE;2-[4-[(1S)-1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid;Lopac-F-9427;SCHEMBL4901;BIDD:GT0790;CHEMBL68381;DTXSID901039730;NCGC00015453-01;PD132680;S-Carboxyterfenadine,S-Terfenadinecarboxylate;EN300-19635389;J-007339;2-{4-[(1S)-1-HYDROXY-4-[4-(HYDROXYDIPHENYLMETHYL)PIPERIDIN-1-YL]BUTYL]PHENYL}-2-METHYLPROPANOIC ACID;4-[(1S)-1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-alpha,alpha-dimethyl-benzeneacetic Acid

Suppliers and Price of (S)-Fexofenadine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-Fexofenadine
10mg
$ 185.00

TRC
(S)-Fexofenadine
100mg
$ 1355.00

Medical Isotopes, Inc.
(S)-Fexofenadine
10 mg
$ 850.00

Medical Isotopes, Inc.
(S)-Fexofenadine
50 mg
$ 1800.00

American Custom Chemicals Corporation
S-FEXOFENADINE 95.00%
100MG
$ 1501.50

American Custom Chemicals Corporation
S-FEXOFENADINE 95.00%
10MG
$ 329.70

Total 2 raw suppliers

Chemical Property of (S)-Fexofenadine

Chemical Property:

Melting Point:141-143°C
PSA：81.00000
LogP:5.44840
Storage Temp.:Refrigerator, Under Inert Atmosphere
Solubility.:Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:501.28790873
Heavy Atom Count:37
Complexity:678

Purity/Quality:

95% ^*data from raw suppliers

(S)-Fexofenadine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
Isomeric SMILES:CC(C)(C1=CC=C(C=C1)[C@H](CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O
Uses A metabolite of of terfenadine, a H1-Histamine receptor antagonist The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist.

Technology Process of (S)-Fexofenadine

There total 84 articles about (S)-Fexofenadine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 154825-96-4
fexofenadine methyl ester

: 83799-24-0,139965-11-0
fexofenadine

Guidance literature:: With water; potassium hydroxide; In ethanol; for 3h; Reagent/catalyst; Solvent; Reflux;

Reference yield: 92.0%

: 50679-08-8
terfenadine

: 83799-24-0,139965-11-0
fexofenadine

Guidance literature:: With Absidia corymbifera LCP 62 1800; YM medium cultured with soybean peptones; In N,N-dimethyl-formamide; at 30 ℃; for 120h;
DOI:10.1016/j.bmcl.2004.07.076