Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI)

Base Information

• Chemical Name: Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI)
• CAS No.: 140379-38-0
• Molecular Formula: C14H13F3N4O3
• Molecular Weight: 0
• Mol file: 140379-38-0.mol

Synonyms:Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI)

Chemical Property of Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI)

Chemical Property:

• PSA: 101.19000
• LogP: 1.33250

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI)

There total 2 articles about Acetamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-5-pyrimidinyl)-2,2,2-trifluoro-N-(phenylmethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione (2034-31-3) + trifluoroacetic acid (76-05-1) → 6-Amino-3-methyl-5-(N-(phenylmethyl)trifluoracetamido)-pyrimidine-2,4-dione (140379-38-0)

Guidance literature:

With dmap; N-ethyl-N'-(3-diethylaminopropyl)-carbodiimide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm9608467

Reference yield:

→ 6-Amino-3-methyl-5-(N-(phenylmethyl)trifluoracetamido)-pyrimidine-2,4-dione (140379-38-0)

Guidance literature:

Reference yield:

2,2,2-trifluoroacetamide (354-38-1) + 6-Amino-3-methyl-5-(N-(phenylmethyl)trifluoracetamido)-pyrimidine-2,4-dione (140379-38-0) → 1-Methyl-7-(phenylmethyl)-8-trifluoromethylpurine-2,6-dione

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide;

upstream raw materials:

6-amino-5-(benzylamino)-3-methylpyrimidine-2,4(1H,3H)-dione

trifluoroacetic acid