GUANYLIN (RAT)

Base Information

• Chemical Name: GUANYLIN (RAT)
• CAS No.: 144940-98-7
• Molecular Formula: C60H90N16O22S4
• Molecular Weight: 1515.71
• Mol file: 144940-98-7.mol

Synonyms:PRO-ASN-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS;PRO-ASN-THR-CYS-GUE-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS;H-PRO-ASN-THR-CYS-GLU-ILE-CYS-ALA-TYR-ALA-ALA-CYS-THR-GLY-CYS-OH;GUANYLIN (RAT);GUANYLIN (RAT, MOUSE);GUANYLIN;H-Pro-Asn-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH(Cys4-Cys12, Cys7-Cys15)

Chemical Property of GUANYLIN (RAT)

Chemical Property:

• PSA: 699.01000
• LogP: -1.59390
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water

Purity/Quality:

99%, ^*data from raw suppliers

GUCA2A ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Biological functions: The primary site of GN action is the intestine where GUCY2C expression is most plentiful. The kidney, liver, gall bladder, bile duct, testis, trachea, salivary glands, and nasal mucosa are also possible target sites. In eels and medaka, the major sites of gucy2c1 and gucy2c2 expression are the intestine and kidney. In the intestine, GN is produced in goblet cells and secreted into the lumen. GN binding to the apically located GUCY2C induces Cl- and HCO3- secretion via CFTR and some SLC26 members and inhibits Na+ absorption via NHE3, which eventually drives intestinal water secretion.GN-GUCY2C signaling suppresses intestinal tumorigenesis. In the intestine, GN is more active at pH 8.0 than at pH 5.0. Circulating and locally produced GN also acts on the renal tubule to induce natriuresis, kariuresis, and diuresis, presumably by affecting the NHE3 and K+ channel(s). However, this GN’s effects could be limited due to the degradation of GN by proteases on the brush border of the renal tubule. In eels, on the other hand, Gn and Rgn affect Cftr in the intestine, but it is notable that Gn and Rgn inhibit Nkcc2 for decreased NaCl absorption and may induce some Slc26 members for HCO3 - secretion under a seawater environment, probably for osmoregulation. In these described actions, GN is often less effective than UGN in mammals while Gn is more effective than Rgn and Ugn in eels. Concerning eel Rgn, its mRNA expression in the intestine and kidney slightly or hardly change after seawater transfer of the fish, suggesting that Rgn may have roles different from those of Gn and Ugn. In a heterologous system, eel Rgn inhibits NHE3 as does rat UGN, but is less effective than rat UGN in the rat perfused renal tubule. In addition, the olfactory GN-GUCY2D signaling in mice suggests more GN functions.
• Description: Guanylin is a peptide hormone consisting of 15 aa residues that binds to the guanylyl cyclase C (GUCY2C) receptor to produce cGMP. It plays an important role in regulating ion and water transport and maintaining epithelial homeostasis in the intestine and kidney. Eel renoguanylin (Rgn) is more similar to GN than to uroguanylin (UGN), and thus is described here.
• Uses: Guanylin (rat, mouse) is an endogenous intestinal guanylyl cyclase activator.
• Clinical Use: Two GN/UGN agonists, linaclotide and plecanatide, have recently been approved in the United States, European Union, Japan, and other countries to treat irritable bowel syndrome and chronic constipation. They have also been approved in the United States to treat chronic idiopathic constipation and irritable bowel syndrome with constipation, respectively.

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