Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester
• CAS No.: 140887-54-3
• Molecular Formula: C₉H₂₀N₂O₃
• Molecular Weight: 204.269
• Mol file: 140887-54-3.mol

Synonyms:Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester

Chemical Property of Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 315.6±32.0 °C(Predicted)
• PKA: 11.68±0.46(Predicted)
• PSA: 73.58000
• Density: 1.022±0.06 g/cm3(Predicted)
• LogP: 1.57600

Purity/Quality:

Tert-Butyl2-Amino-1-(Methoxymethyl)Ethylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester

There total 2 articles about Carbamic acid, [2-amino-1-(methoxymethyl)ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-tert-butoxycarbonylamino-3-methoxypropionitrile (140887-51-0) → 2-tert-butoxycarbonyl-3-methoxy-1-propylamine (140887-54-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 2h; Heating;

DOI:10.1055/s-1992-26094

Reference yield:

1-(tert-butoxycarbonyl)-2-cyanoaziridine (67276-82-8) → 2-tert-butoxycarbonyl-3-methoxy-1-propylamine (140887-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Et₂O*BF₃ / 12 h / Ambient temperature

2: 78 percent / LiAlH₄ / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; In diethyl ether;

DOI:10.1055/s-1992-26094

upstream raw materials:

2-tert-butoxycarbonylamino-3-methoxypropionitrile

1-(tert-butoxycarbonyl)-2-cyanoaziridine

Refernces