3-Amino-1-benzyl-3-cyanopyrrolidine

Base Information

• Chemical Name: 3-Amino-1-benzyl-3-cyanopyrrolidine
• CAS No.: 145090-28-4
• Molecular Formula: C12H15 N3
• Molecular Weight: 201.271
• Mol file: 145090-28-4.mol

Synonyms:3-Pyrrolidinecarbonitrile,3-amino-1-(phenylmethyl)-, (?à)-; 3-Amino-3-cyano-1-benzylpyrrolidine

Chemical Property of 3-Amino-1-benzyl-3-cyanopyrrolidine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.603
• Boiling Point: 342.2°Cat760mmHg
• Flash Point: 160.8°C
• PSA: 53.05000
• Density: 1.15g/cm³
• LogP: 1.75158

Purity/Quality:

99%min ^*data from raw suppliers

3-Amino-1-benzylpyrrolidine-3-carbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-1-benzyl-3-cyanopyrrolidine

There total 4 articles about 3-Amino-1-benzyl-3-cyanopyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

potassium cyanide + N-benzyl-3-pyrrolidinone (775-16-6) → 3-Amino-1-benzyl-pyrrolidine-3-carbonitrile (145090-28-4)

Guidance literature:

With ammonium carbonate; In ethanol; for 3h; Reflux;

Reference yield: 70.0%

N-benzyl-3-pyrrolidinone (775-16-6) → 3-Amino-1-benzyl-pyrrolidine-3-carbonitrile (145090-28-4)

Guidance literature:

With ammonium chloride; potassium carbonate; In ammonia; isopropyl alcohol;

Reference yield:

N-benzyl-3-pyrrolidinone (775-16-6) + sodium cyanide (143-33-9,25596-52-5) → 3-Amino-1-benzyl-pyrrolidine-3-carbonitrile (145090-28-4)

Guidance literature:

With ammonia; magnesium sulfate; ammonium chloride; In methanol; at 60 ℃;

DOI:10.1016/j.bmcl.2007.02.046

upstream raw materials:

N-benzyl-3-pyrrolidinone

sodium cyanide

Downstream raw materials:

3-amino-1-benzylpyrrolidine-3-carboxylic acid

Refernces

• 1、 Bekkali, Younes,Thomson, David S.,Betageri, Raj,Emmanuel, Michel J.,Hao, Ming-Hong,Hickey, Eugene,Liu, Weimin,Patel, Usha,Ward, Yancey D.,Young, Erick R.R.,Nelson, Richard,Kukulka, Alison,Brown, Maryanne L.,Crane, Kathy,White, Della,Freeman, Dorothy M.,Labadia, Mark E.,Wildeson, Jessi,Spero, Denice M.. "Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors". . p. 2465 - 2469. Retrieved 2008/03/11.
• 2、 -. "Antiallergic cosmetic or pharmaceutical composition". . . Retrieved 2008/06/13.