2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI)

Base Information

• Chemical Name: 2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI)
• CAS No.: 145165-95-3
• Molecular Formula: C9H12 N2
• Molecular Weight: 148.21
• Hs Code.: 2933399090
• Mol file: 145165-95-3.mol

Synonyms:2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI)

Chemical Property of 2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI)

Chemical Property:

• PSA: 38.91000
• LogP: 2.35780

Purity/Quality:

99%min ^*data from raw suppliers

(S)-1-PYRIDIN-2-YL-BUT-3-ENYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI)

There total 4 articles about 2-Pyridinemethanamine,alpha-2-propenyl-,(S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(S)-1-(2-pyridyl)-3-butenylamino]-3-methyl-1-butanol (181868-15-5) → (S)-1-Pyridin-2-yl-but-3-enylamine (145165-95-3)

Guidance literature:

With periodic acid; methylamine; In methanol; for 1h; Yield given;

DOI:10.1016/0957-4166(96)00251-0

Reference yield:

C13H20N2OS → (S)-1-Pyridin-2-yl-but-3-enylamine (145165-95-3)

Guidance literature:

With triethylamine; In acetonitrile; for 20h; Reflux; Inert atmosphere;

DOI:10.1021/acs.orglett.6b03603

Reference yield:

methyl N-(2-pyridylmethylidene)-(S)-valinate (90472-55-2) → (S)-1-Pyridin-2-yl-but-3-enylamine (145165-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) PbBr₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 30 min

2: 95 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 - 5 °C

3: 40percent aq. MeNH₂, H₅IO₆ / methanol / 1 h

With lithium aluminium tetrahydride; lead(II) bromide; periodic acid; methylamine; In tetrahydrofuran; methanol;

DOI:10.1016/0957-4166(96)00251-0

upstream raw materials:

(S)-2-[(S)-1-(2-pyridyl)-3-butenylamino]-3-methyl-1-butanol

methyl N-(2-pyridylmethylidene)-(S)-valinate

(S)-3-Methyl-2-((S)-1-pyridin-2-yl-but-3-enylamino)-butyric acid methyl ester

Refernces

• 1、 Fiorelli, Claudio,Savoia, Diego. "Asymmetric synthesis of δ-substituted α,β-unsaturated δ-lactams by ring closing metathesis of enantiomerically pure N-acryloyl-homoallylic amines". . p. 6022 - 6028. Retrieved 2008/02/10.