methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate
CAS No.:141327-54-0
Molecular Formula:C17H14 F N O2
Molecular Weight:283.2969632
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00439018
Wikidata:Q82254887
Mol file:141327-54-0.mol

Synonyms:141327-54-0;methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate;METHYL 3-(4-FLUOROPHENYL)-5-METHYLINDOLE-2-CARBOXYLATE;1H-Indole-2-carboxylic acid, 3-(4-fluorophenyl)-5-methyl-, methyl ester;SCHEMBL9264953;DTXSID00439018;TVRIEWUGJXZDQN-UHFFFAOYSA-N;AKOS015965086;EC-000.1720;Boc-(R)-3-Amino-4-(3-methylphenyl)butanoicacid;methyl3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate;3-(4-Fluoro-phenyl)-5-methyl-1H-indole-2-carboxylic acid methyl ester

Suppliers and Price of methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL 3-(4-FLUOROPHENYL)-5-METHYLINDOLE-2-CARBOXYLATE 95.00%
5MG
$ 505.73

Total 3 raw suppliers

Chemical Property of methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate

Chemical Property:

Vapor Pressure:3.06E-09mmHg at 25°C
Refractive Index:1.624
Boiling Point:476.4°C at 760 mmHg
Flash Point:241.9°C
PSA：42.09000
Density:1.256g/cm³
LogP:4.06900
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:283.10085685
Heavy Atom Count:21
Complexity:381

Purity/Quality:

95% ^*data from raw suppliers

METHYL 3-(4-FLUOROPHENYL)-5-METHYLINDOLE-2-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(C=C1)NC(=C2C3=CC=C(C=C3)F)C(=O)OC

Technology Process of methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate

There total 1 articles about methyl 3-(4-fluorophenyl)-5-methyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-tolylhydrazone of methyl 2-oxo-3-(4-fluorophenyl)propanoate

: 141327-54-0
methyl 5-methyl-3-(4-fluorophenyl)-1H-indole-2-carboxylate

Guidance literature:: With sulfuric acid; In methanol; for 18h; Yield given; Heating;
DOI:10.1021/jm00104a007

Reference yield:

: 141327-54-0
methyl 5-methyl-3-(4-fluorophenyl)-1H-indole-2-carboxylate

: 141306-22-1
3-(4-fluorophenyl)-5-methyl-1-(4-piperidyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / methanol / 1 h / Heating

2: copper / various solvent(s) / 120 h / Heating

3: K₂CO₃, CuBr / various solvent(s) / 18 h / Heating

4: H₂ / PtO₂ / acetic acid / 72 h / 2280 Torr

With sodium hydroxide; hydrogen; copper; potassium carbonate; copper(I) bromide; platinum(IV) oxide; In methanol; acetic acid;
DOI:10.1021/jm00104a007

Reference yield:

: 141327-54-0
methyl 5-methyl-3-(4-fluorophenyl)-1H-indole-2-carboxylate

: 141306-35-6
1-<2-<4-<3-(4-fluorophenyl)-5-methyl-1H-indol-1-yl>-1-piperidinyl>ethyl>-2-imidazolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / methanol / 1 h / Heating

2: copper / various solvent(s) / 120 h / Heating

3: K₂CO₃, CuBr / various solvent(s) / 18 h / Heating

4: H₂ / PtO₂ / acetic acid / 72 h / 2280 Torr

5: K₂CO₃, KI / various solvent(s) / 18 h / Heating

With sodium hydroxide; hydrogen; copper; potassium carbonate; potassium iodide; copper(I) bromide; platinum(IV) oxide; In methanol; acetic acid;
DOI:10.1021/jm00104a007