2-(Triisopropylsilyl)-1,3-dithiane

Base Information

• Chemical Name: 2-(Triisopropylsilyl)-1,3-dithiane
• CAS No.: 145251-89-4
• Molecular Formula: C13H28 S2 Si
• Molecular Weight: 276.583
• Hs Code.: 2934999090
• European Community (EC) Number: 681-067-9
• DSSTox Substance ID: DTXSID20404723
• Nikkaji Number: J1.096.584E
• Mol file: 145251-89-4.mol

Synonyms:2-(Triisopropylsilyl)-1,3-dithiane;145251-89-4;1,3-dithian-2-yl-tri(propan-2-yl)silane;2-Triisopropylsilyl-1,3-dithiane;(1,3-Dithian-2-yl)triisopropylsilane;2-(TRIISOPROPYLSILYL)-1 3-DITHIANE 97;DTXSID20404723;AKOS015912740;2-(Triisopropylsilyl)-1,3-dithiane, 97%;J-008079

Chemical Property of 2-(Triisopropylsilyl)-1,3-dithiane

Chemical Property:

• Vapor Pressure: 0.13mmHg at 25°C
• Melting Point: 46-49 °C(lit.)
• Refractive Index: 1.417
• Boiling Point: 225.3°C at 760 mmHg
• Flash Point: >230 °F
• PSA: 50.60000
• Density: 0.854g/cm³
• LogP: 5.82050
• Sensitive.: Air Sensitive
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 276.14016977
• Heavy Atom Count: 16
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

2-(Triisopropylsilyl)-1,3-dithiane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[Si](C1SCCCS1)(C(C)C)C(C)C

Technology Process of 2-(Triisopropylsilyl)-1,3-dithiane

There total 2 articles about 2-(Triisopropylsilyl)-1,3-dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-lithio-1,3-dithiane (36049-90-8) + triisopropylsilyl chloride (13154-24-0) → 2-triisopropylsilyl-1,3-dithiane (145251-89-4)

Guidance literature:

at -78 - 25 ℃; for 3h;

DOI:10.1021/ja00051a060

Reference yield:

1,3 dithiane (505-23-7) + triisopropylsilyl chloride (13154-24-0) → 2-triisopropylsilyl-1,3-dithiane (145251-89-4)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -35 deg C, 1 h, 2.) THF, hexane, from -35 deg C to RT, 3 h;

DOI:10.1016/0040-4020(95)01029-7

Reference yield: 86.0%

cis-1-Cyclohexyl-2-vinyloxirane (77131-98-7) + 2-triisopropylsilyl-1,3-dithiane (145251-89-4) → (E)-1-Cyclohexyl-4-(2-triisopropylsilanyl-[1,3]dithian-2-yl)-but-2-en-1-ol

Guidance literature:

2-triisopropylsilyl-1,3-dithiane; With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -25 ℃; for 1h;

cis-1-Cyclohexyl-2-vinyloxirane; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 3h;

DOI:10.1021/ja0376238

upstream raw materials:

2-lithio-1,3-dithiane

triisopropylsilyl chloride

1,3 dithiane

Downstream raw materials:

phenyl(triisopropylsilyl)methanol

(2R,3S)-3-Hydroxy-2-methyl-1-phenyl-3-triisopropylsilanyl-propan-1-one

(2S,3S)-3-Hydroxy-2-methyl-1-phenyl-3-triisopropylsilanyl-propan-1-one