Carbamic acid, [(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 145296-43-1
• Molecular Formula: C9H17 N O4
• Molecular Weight: 203.23558
• Mol file: 145296-43-1.mol

Synonyms:Carbamicacid, (1-formyl-2-methoxyethyl)-, 1,1-dimethylethyl ester, (S)-; Carbamic acid,[(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 302.1±32.0 °C(Predicted)
• PKA: 10.91±0.46(Predicted)
• PSA: 64.63000
• Density: 1.050±0.06 g/cm3(Predicted)
• LogP: 1.11590

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI)

There total 4 articles about Carbamic acid, [(1S)-1-formyl-2-methoxyethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((S)-2-Benzyloxy-1-methoxymethyl-ethyl)-carbamic acid tert-butyl ester (183793-48-8) → (S)-tert-butyl 1-methoxy-3-oxopropan-2-ylcarbamate (145296-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / Pd/C / methanol / 24 h

2: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, 15 min, -78 deg C, 2.) CH₂Cl₂, room temp., 2.5 h

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1021/jo961408a

Reference yield:

(R)-tert-butyl 1-methoxybut-3-en-2-ylcarbamate → (S)-tert-butyl 1-methoxy-3-oxopropan-2-ylcarbamate (145296-43-1)

Guidance literature:

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; toluene; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c5ra06609c

Reference yield:

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate (134167-07-0) → (S)-tert-butyl 1-methoxy-3-oxopropan-2-ylcarbamate (145296-43-1)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 6.5h; Inert atmosphere;

DOI:10.1055/s-0029-1218843

upstream raw materials:

(R)-tert-butyl 1-hydroxy-3-methoxy propan-2-yl carbamate

((S)-2-Benzyloxy-1-methoxymethyl-ethyl)-carbamic acid tert-butyl ester

(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-methoxypropanoate