(3-Aminonaphthalen-2-yl)methanol

Base Information

• Chemical Name: (3-Aminonaphthalen-2-yl)methanol
• CAS No.: 141281-58-5
• Molecular Formula: C11H11 N O
• Molecular Weight: 173.214
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID00438844
• Wikidata: Q82254678
• ChEMBL ID: CHEMBL1935085
• Mol file: 141281-58-5.mol

Synonyms:(3-aminonaphthalen-2-yl)methanol;141281-58-5;3-AMINO-2-HYDROXYMETHYLNAPHTHALENE;3-AMINO-4-HYDROXYMETHYLNAPHTHALENE;CHEMBL1935085;2-Naphthalenemethanol,3-amino-(9CI);2-Aminonaphthalene-3-methanol;SCHEMBL647376;(3-amino-2-naphthyl)methanol;DTXSID00438844;JISDTJXWUKAFFL-UHFFFAOYSA-N;2-amino-3-hydroxymethylnaphthalene;(3-aminonaphthalen-2-yl)-methanol;3-Amino-2-hydroxymethyl naphthalene;BDBM50360483;MFCD00155332;AKOS006272444;SB84065;BS-24914;A885687

Chemical Property of (3-Aminonaphthalen-2-yl)methanol

Chemical Property:

• Boiling Point: 397.4±17.0 °C(Predicted)
• PKA: 14.23±0.10(Predicted)
• PSA: 46.25000
• Density: 1.240±0.06 g/cm3(Predicted)
• LogP: 2.49550
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 173.084063974
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

97% ^*data from raw suppliers

(3-aminonaphthalen-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)CO)N

Technology Process of (3-Aminonaphthalen-2-yl)methanol

There total 5 articles about (3-Aminonaphthalen-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyl 3-amino-2-naphthoate (21597-54-6) → 3-Amino-2-(hydroxymethyl)naphthalene (141281-58-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h; Cooling with ice;

Reference yield: 95.0%

2-Amino-3-naphthoic acid (5959-52-4) → 3-Amino-2-(hydroxymethyl)naphthalene (141281-58-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

3-Hydroxy-2-naphthoic acid (92-70-6) → 3-Amino-2-(hydroxymethyl)naphthalene (141281-58-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / 30percent aq. NH₃, ZnCl₂ / 36 h / 195 °C

2: 60 percent / conc. H₂SO₄ / Heating

3: 75 percent / LiAlH₄ / tetrahydrofuran / 2 h / 5 °C

With ammonium hydroxide; lithium aluminium tetrahydride; sulfuric acid; zinc(II) chloride; In tetrahydrofuran;

DOI:10.1021/jo00083a024

upstream raw materials:

2-Amino-3-naphthoic acid

Methyl 3-amino-2-naphthoate

sulfuric acid

3-Hydroxy-2-naphthoic acid

Downstream raw materials:

3-amino naphthalene-2-carboxaldehyde

14-(p-tolyl)-4b,6-dihydronaphtho[2',3':4,5][1,3]oxazino[2,3-a]isoquinoline

2-methyl-14-phenyl-4b,6-dihydronaphtho[2',3':4,5][1,3]oxazino[2,3-a]isoquinoline

N-(3-formylnaphthalen-2-yl)-4-methylbenzenesulfonamide