2(1H)-Quinoxalinone, 7-fluoro-

Base Information

• Chemical Name: 2(1H)-Quinoxalinone, 7-fluoro-
• CAS No.: 145323-53-1
• Molecular Formula: C8H5 F N2 O
• Molecular Weight: 164.14
• Mol file: 145323-53-1.mol

Synonyms:7-Fluoroquinoxalin-2(1H)-one

Chemical Property of 2(1H)-Quinoxalinone, 7-fluoro-

Chemical Property:

• PSA: 45.75000
• LogP: 1.06220

Purity/Quality:

98%min ^*data from raw suppliers

7-Fluoroquinoxalin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Fluoroquinoxalin-2(1H)-one was used as a reagent in the development and optimization of novel bacterial topoisomerase type II inhibitors which show potential for use in development of antimicrobial agents against drug resistant pseudomonas aeruginosa.

Technology Process of 2(1H)-Quinoxalinone, 7-fluoro-

There total 7 articles about 2(1H)-Quinoxalinone, 7-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

7-fluoro-1,2,3,4-tetrahydroquinoxalin-2-one (66367-11-1) → 7-fluoro-quinoxalin-2-ol (145323-53-1)

Guidance literature:

7-fluoro-1,2,3,4-tetrahydroquinoxalin-2-one; With dihydrogen peroxide; sodium hydroxide; In water; for 2h; Reflux; Inert atmosphere;

With acetic acid; In water;

Reference yield:

N-(4-fluoro-2-nitrophenyl)sarcosine ethyl ester (145323-37-1) → 5-fluoro-1H-benzimidazole 3-oxide (118807-95-7) + 7-fluoro-1,2-dihydroquinoxalin-2-one (145323-53-1) + 6-Fluoro-4-hydroxy-1-methyl-1,4-dihydro-quinoxaline-2,3-dione (145323-52-0) + 6-fluoroquinoxalin-2(1H)-one (55687-23-5)

Guidance literature:

With potassium carbonate; In ethanol; for 4.5h; Further byproducts given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)80466-X

Reference yield:

7-fluoro-1,2,3,4-tetrahydroquinoxalin-2-one (66367-11-1) → 7-fluoro-1,2-dihydroquinoxalin-2-one (145323-53-1)

Guidance literature:

7-fluoro-1,2,3,4-tetrahydroquinoxalin-2-one; With dihydrogen peroxide; sodium hydroxide; In water; at 80 ℃;

With acetic acid; In water; at 20 ℃;

DOI:10.1016/j.bmc.2014.07.040

upstream raw materials:

N-(4-fluoro-2-nitrophenyl)sarcosine ethyl ester

glyoxylic acid ethyl ester

4-fluoro-1,2-phenylenediamine

2-nitro-4-fluoroaniline

Downstream raw materials:

2-chloro-7-fluoroquinoxaline

2-chloro-6-fluoro-quinoxaline

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