1H-Pyrazole-4-carboxylicacid, 1-ethoxy-2,3-dihydro-3-oxo-, ethyl ester

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxylicacid, 1-ethoxy-2,3-dihydro-3-oxo-, ethyl ester
• CAS No.: 145325-80-0
• Molecular Formula: C₈H₁₂N₂O₄
• Molecular Weight: 200.194
• Mol file: 145325-80-0.mol

Synonyms:1H-Pyrazole-4-carboxylicacid,1-ethoxy-2,3-dihydro-3-oxo-,ethylester(9CI)

Chemical Property of 1H-Pyrazole-4-carboxylicacid, 1-ethoxy-2,3-dihydro-3-oxo-, ethyl ester

Chemical Property:

• Boiling Point: 160 °C (0.1 mmHg)
• PSA: 73.32000
• LogP: -0.19840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-4-carboxylicacid, 1-ethoxy-2,3-dihydro-3-oxo-, ethyl ester

There total 2 articles about 1H-Pyrazole-4-carboxylicacid, 1-ethoxy-2,3-dihydro-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-cyanomalonate (4513-67-1) + diethyl N-ethoxyaminomethylenemalonate (145325-85-5) + ethyl 1-ethoxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (145325-80-0) + ethyl 5-ethoxyisoxazole-4-carboxylate (28783-55-3)

Guidance literature:

With sodium azide; trifluoroacetic acid; at 20 ℃; for 12h; Further byproducts given;

DOI:10.1071/CH9921571

Reference yield: 67.0%

diethyl 2-ethoxymethylenemalonate (87-13-8) → diethyl 2-cyanomalonate (4513-67-1) + diethyl N-ethoxyiminomethylmalonate (145325-83-3,145325-86-6) + ethyl 1-ethoxy-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (145325-80-0) + ethyl 5-ethoxyisoxazole-4-carboxylate (28783-55-3)

Guidance literature:

With sodium azide; trifluoroacetic acid; at 20 ℃; for 12h; Yield given. Further byproducts given. Title compound not separated from byproducts;

DOI:10.1071/CH9921571

upstream raw materials:

diethyl 2-ethoxymethylenemalonate