Pyrido[1,2-a]benzimidazol-7-amine

Base Information

• Chemical Name: Pyrido[1,2-a]benzimidazol-7-amine
• CAS No.: 696636-30-3
• Molecular Formula: C11H9N3
• Molecular Weight: 183.20926
• DSSTox Substance ID: DTXSID40363621
• Nikkaji Number: J2.382.656I
• Wikidata: Q82147345
• Mol file: 696636-30-3.mol

Synonyms:pyrido[1,2-a]benzimidazol-7-amine;696636-30-3;SCHEMBL832842;DTXSID40363621;7-amino-pyrido[1,2-a]benzimidazole;STK683045;Pyrido[1,2-a]benzoimidazole-7-amine;AKOS005597129;Benzo[4,5]imidazo[1,2-a]pyridin-7-ylamine

Chemical Property of Pyrido[1,2-a]benzimidazol-7-amine

Chemical Property:

• PSA: 43.32000
• LogP: 2.65090
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 183.079647300
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC3=C(N2C=C1)C=CC(=C3)N

Technology Process of Pyrido[1,2-a]benzimidazol-7-amine

There total 3 articles about Pyrido[1,2-a]benzimidazol-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(2,4-dinitrophenyl)-pyridinium chloride (4185-69-7) → 8-aminobenzo[4,5]imidazo[1,2-a]pyridine (696636-30-3)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In ethanol; at 20 ℃; for 0.166667h;

DOI:10.1023/B:COHC.0000048302.21953.6a

Reference yield: 97.0%

Cl(1-)*C11H10N3O2(1+) (1323269-99-3) → 8-aminobenzo[4,5]imidazo[1,2-a]pyridine (696636-30-3)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; In water; isopropyl alcohol; at 20 ℃; for 0.166667h;

DOI:10.1134/S1070428013050291

Reference yield: 50.7%

1-(2,4-dinitrophenyl)-pyridinium chloride (4185-69-7) → 8-aminobenzo[4,5]imidazo[1,2-a]pyridine (696636-30-3) + 8-nitrobenzo[4,5]imidazo[1,2-a]pyridine (71190-34-6)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In water; isopropyl alcohol; at 20 ℃; for 0.0833333h; Concentration; Overall yield = 93.1 %; Inert atmosphere;

DOI:10.1134/S1070428014080296

upstream raw materials:

1-(2,4-dinitrophenyl)-pyridinium chloride

Cl^(1-)*C₁₁H₁₀N₃O₂⁽¹⁺⁾

Downstream raw materials:

N-(pyrido[1,2-a]benzimidazol-7-yl)-5-fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide