4-Methylidene-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione

Base Information

• Chemical Name: 4-Methylidene-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione
• CAS No.: 141509-41-3
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.179
• DSSTox Substance ID: DTXSID00569627
• Mol file: 141509-41-3.mol

Synonyms:141509-41-3;4-methylidene-1-oxa-7,10-diazaspiro[4.5]decane-6,9-dione;1-Oxa-6,9-diazaspiro[4.5]decane-7,10-dione,4-methylene-(9CI);DTXSID00569627;4-METHYLIDENE-1-OXA-6,9-DIAZASPIRO[4.5]DECANE-7,10-DIONE

Chemical Property of 4-Methylidene-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione

Chemical Property:

• PSA: 74.41000
• LogP: -0.54300
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 182.06914219
• Heavy Atom Count: 13
• Complexity: 300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=C1CCOC12C(=O)NCC(=O)N2

Technology Process of 4-Methylidene-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione

There total 3 articles about 4-Methylidene-1-oxa-6,9-diazaspiro[4.5]decane-7,10-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

3-(3-hydroxy-1-(hydroxymethyl)propylidene)-2,5-piperazinedione (141509-47-9,141509-48-0) → 4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione (141509-41-3)

Guidance literature:

With potassium hydrogencarbonate; methanesulfonyl chloride; In 1,4-dioxane; for 15h; Heating;

DOI:10.1021/jo00039a028

Reference yield:

1-acetyl-3-(4,4-dimethyl-3,5-dioxacycloheptylidene)-2,5-piperazinedione (141509-43-5,141509-44-6) → 4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione (141509-41-3)

Guidance literature:

Multistep reaction; (i) N₂H₄*H₂O, (ii) AcOH, H₂O, (iii) MeSO₂Cl, KHCO₃;

DOI:10.1021/ja00489a057

Reference yield:

3-(4,4-dimethyl-3,5-dioxacycloheptylidene)-2,5-piperazinedione (141509-45-7,141509-46-8) → 4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione (141509-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 50percent aq. HOAc / 2 h / Ambient temperature

2: 26 percent / methanesulfonyl chloride, KHCO₃ / dioxane / 15 h / Heating

With potassium hydrogencarbonate; acetic acid; methanesulfonyl chloride; In 1,4-dioxane;

DOI:10.1021/jo00039a028

upstream raw materials:

1-acetyl-3-(4,4-dimethyl-3,5-dioxacycloheptylidene)-2,5-piperazinedione

3-(3-hydroxy-1-(hydroxymethyl)propylidene)-2,5-piperazinedione

3-(4,4-dimethyl-3,5-dioxacycloheptylidene)-2,5-piperazinedione

Downstream raw materials:

glycinamide hydrochloride

3-hydroxy-4-(2-hydroxyethyl)-2(5H)-furanone