5-METHOXY-3-METHYLBENZODISOXAZOLE

Base Information

• Chemical Name: 5-METHOXY-3-METHYLBENZODISOXAZOLE
• CAS No.: 145508-90-3
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.17326
• Mol file: 145508-90-3.mol

Synonyms:5-Methoxy-3-methyl-1,2-benzisoxazole

Chemical Property of 5-METHOXY-3-METHYLBENZODISOXAZOLE

Chemical Property:

• PSA: 35.26000
• LogP: 2.14480

Purity/Quality:

97% ^*data from raw suppliers

5-METHOXY-3-METHYLBENZO[D]ISOXAZOLE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-3-METHYLBENZODISOXAZOLE

There total 8 articles about 5-METHOXY-3-METHYLBENZODISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-hydroxy-5-methoxyacetophenone oxime (23997-97-9) → 5-methoxy-3-methyl-1,2-benzisoxazole (145508-90-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.bmc.2013.03.071

Reference yield: 79.0%

(Z)-1-(2-bromophenyl)ethanone oxime (1215858-72-2) → 5-methoxy-3-methyl-1,2-benzisoxazole (145508-90-3)

Guidance literature:

(Z)-1-(2-bromophenyl)ethanone oxime; With sodium t-butanolate; In tetrahydrofuran; at 23 ℃; for 0.5h; Inert atmosphere;

With copper(l) iodide; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 23 ℃; for 1.08333h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.12.070

Reference yield:

5-hydroxy-3-methylbenzo[d]isoxazole (214760-36-8) + dimethyl sulfate (77-78-1) → 5-methoxy-3-methyl-1,2-benzisoxazole (145508-90-3)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃;

upstream raw materials:

dimethyl sulfate

(Z)-1-(2-bromophenyl)ethanone oxime

(E)-2-hydroxy-5-methoxyacetophenone oxime

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

Downstream raw materials:

benzyl 1-(2-hydroxy-5-methoxyphenyl)-1-ethylcarbamate