3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID

Base Information

• Chemical Name: 3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID
• CAS No.: 145743-83-5
• Molecular Formula: C₁₅H₁₈O₄
• Molecular Weight: 262.306
• Mol file: 145743-83-5.mol

Synonyms:RARECHEM AL BK 0458;3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID

Chemical Property of 3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID

Chemical Property:

• Vapor Pressure: 2.93E-08mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 432.8°Cat760mmHg
• Flash Point: 160.9°C
• PSA: 55.76000
• Density: 1.204g/cm³
• LogP: 3.11440

Purity/Quality:

98%min ^*data from raw suppliers

3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID

There total 13 articles about 3-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bromoacetic acid (79-08-3) + 3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → (E)-3-(3-cyclopentyloxy-4-methoxyphenyl)-2-propenoic acid (133332-31-7,145743-83-5)

Guidance literature:

bromoacetic acid; With triethyl phosphate; sodium hydride; In 1,2-dimethoxyethane; at 20 ℃; for 4h;

3-cyclopentyloxy-4-methoxybenzylaldehyde; In 1,2-dimethoxyethane; at 20 ℃; for 24h; Further stages.;

DOI:10.1021/ja027313+

Reference yield: 90.0%

malonic acid (141-82-2) + 3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → 3-[3-(cyclopentyloxy)-4-methoxyphenyl]acrylic acid (145743-83-5)

Guidance literature:

With N,N-dimethyl-formamide dimethyl acetal; triethylamine; In toluene; for 4h; Reflux;

Reference yield: 90.0%

malonic acid (141-82-2) + 3-cyclopentyloxy-4-methoxybenzylaldehyde (67387-76-2) → (E)-3-(3-cyclopentyloxy-4-methoxyphenyl)-2-propenoic acid (133332-31-7,145743-83-5)

Guidance literature:

With 1,1-dimethoxyethane; triethylamine; In N,N-dimethyl-formamide; toluene; at 80 ℃; for 4h;

DOI:10.1021/jm500855w

upstream raw materials:

(E)-methyl-3-<3-(cyclopenyloxy)-4-methoxyphenyl>prop-2-enoate

bromoacetic acid

3-cyclopentyloxy-4-methoxybenzylaldehyde

isovanillin

Downstream raw materials:

3-[3-(cyclopentyloxy)-4-methoxyphenyl]propanoic acid

Refernces

• 1、 -. "NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY". Page/Page column 50-51. . Retrieved 2015/09/22.
• 2、 Itoh, Kennosuke,Kanemasa, Shuji. "Enantioselective Michael additions of nitromethane by a catalytic double activation method using chiral Lewis acid and achiral amine catalysts". . p. 13394 - 13395. Retrieved 2007/10/03.