4,5-Dianilinophthalimide

Base Information

Chemical Name:4,5-Dianilinophthalimide
CAS No.:145915-58-8
Deprecated CAS:157168-02-0
Molecular Formula:C20H15 N3 O2
Molecular Weight:329.358
Hs Code.:
European Community (EC) Number:406-050-3
UNII:Z13D008FZ2
DSSTox Substance ID:DTXSID4040393
Nikkaji Number:J587.895K
Wikidata:Q27123966
Metabolomics Workbench ID:58551
ChEMBL ID:CHEMBL268868
Mol file:145915-58-8.mol

Synonyms:4,5-dianilinophthalimide;CGP 52411;CGP 53353;CGP 54211;CGP-52411;CGP53353;DAPH1

Suppliers and Price of 4,5-Dianilinophthalimide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CGP52411
5mg
$ 300.00

Sigma-Aldrich
DAPH ≥98% (HPLC), solid
25mg
$ 636.00

Sigma-Aldrich
DAPH ≥98% (HPLC), solid
5mg
$ 160.00

CSNpharm
CGP?52411
10mg
$ 90.00

CSNpharm
CGP?52411
5mg
$ 53.00

ChemScene
CGP52411 99.82%
5mg
$ 660.00

Cayman Chemical
DAPH
10mg
$ 234.00

Cayman Chemical
DAPH
5mg
$ 127.00

Cayman Chemical
DAPH
1mg
$ 39.00

Cayman Chemical
DAPH
25mg
$ 536.00

Total 8 raw suppliers

Chemical Property of 4,5-Dianilinophthalimide

Chemical Property:

Melting Point:199-202℃
PKA:9.06±0.20(Predicted)
PSA：70.23000
Density:1.374
LogP:4.53220
Storage Temp.:2-8°C
Solubility.:DMSO: ~30 mg/mL
XLogP3:3.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:329.116426730
Heavy Atom Count:25
Complexity:453

Purity/Quality:

97% ^*data from raw suppliers

CGP52411 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 36/37

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4
Uses CGP 52411 is a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitmuor activity. It may offer therapeutic agents for the treatment of hyperproliferative diseases.

Technology Process of 4,5-Dianilinophthalimide

There total 5 articles about 4,5-Dianilinophthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 130672-95-6
4,5-bis(phenylamino)phthalic acid dimethyl ester

: 145915-58-8,157168-02-0
5,6-bis-phenylamino-isoindole-1,3-dione

Guidance literature:: With ammonia; In ethylene glycol; at 120 ℃; for 16h;
DOI:10.1021/jm00033a019

Reference yield:

: 159715-92-1
4,5-bis(anilino)phthalic anhydride

: 145915-58-8,157168-02-0
5,6-bis-phenylamino-isoindole-1,3-dione

Guidance literature:: With formamide; In water;

Reference yield:

: 62-53-3
aniline

: 145915-58-8,157168-02-0
5,6-bis-phenylamino-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / acetic acid / 3 h / Heating

2: 59 percent / ammonia gas / ethane-1,2-diol / 16 h / 120 °C

With ammonia; In ethylene glycol; acetic acid;
DOI:10.1021/jm00033a019