4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one

Base Information

Chemical Name:4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one
CAS No.:142183-74-2
Molecular Formula:C₁₀H₁₃ClO₃
Molecular Weight:216.664
Hs Code.:
DSSTox Substance ID:DTXSID60577167
Mol file:142183-74-2.mol

Synonyms:142183-74-2;4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one;1-Oxaspiro[4.4]nonan-2-one, 4-(chloroacetyl)- (9CI);4-(Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one;DTXSID60577167

Suppliers and Price of 4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-OXASPIRO[4.4]NONAN-2-ONE, 4-(CHLOROACETYL)- 95.00%
5MG
$ 496.25

Total 1 raw suppliers

Chemical Property of 4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one

Chemical Property:

Boiling Point:393.5±32.0 °C(Predicted)
PSA：43.37000
Density:1.27±0.1 g/cm3(Predicted)
LogP:1.67020
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:216.0553220
Heavy Atom Count:14
Complexity:269

Purity/Quality:: 1-OXASPIRO[4.4]NONAN-2-ONE, 4-(CHLOROACETYL)- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2(C1)C(CC(=O)O2)C(=O)CCl

Technology Process of 4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one

There total 3 articles about 4-(2-Chloroacetyl)-1-oxaspiro[4.4]nonan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 142183-70-8
2-oxo-1-oxaspiro<4,4>nonan-4-carbonyl chloride

: 142183-74-2
2-oxo-4-chloroacetyl-1-oxaspiro<4,4>nonane

Guidance literature:: With hydrogenchloride; In diethyl ether; for 1h;
DOI:10.1007/BF01171302

Reference yield:

: 18363-10-5
2-oxo-1-oxaspiro<4,4>nonan-4-carboxylic acid

: 142183-74-2
2-oxo-4-chloroacetyl-1-oxaspiro<4,4>nonane

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / SOCl₂ / benzene / 6 h

2: 60 percent / conc. HCl / diethyl ether / 1 h

With hydrogenchloride; thionyl chloride; In diethyl ether; benzene;
DOI:10.1007/BF01171302

Reference yield:

: 2-oxo-1-oxaspiro<4,4>nonan-3,4-dicarboxylic acid diethyl ester

: 142183-74-2
2-oxo-4-chloroacetyl-1-oxaspiro<4,4>nonane

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / conc. HCl / 5 h / Heating

2: 90 percent / SOCl₂ / benzene / 6 h

3: 60 percent / conc. HCl / diethyl ether / 1 h

With hydrogenchloride; thionyl chloride; In diethyl ether; benzene;
DOI:10.1007/BF01171302