Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI)

Base Information

Chemical Name:Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI)
CAS No.:146400-25-1
Molecular Formula:C₇H₁₃NO₃
Molecular Weight:159.185
Hs Code.:
Mol file:146400-25-1.mol

Synonyms:Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI)

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Chemical Property of Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI)

Chemical Property:

Boiling Point:299.1±15.0 °C(Predicted)
PKA:2.93±0.50(Predicted)
Density:1.238±0.06 g/cm3(Predicted)

Purity/Quality:

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Technology Process of Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI)

There total 9 articles about Cyclopropanecarboxylic acid, 1-amino-3-(hydroxymethyl)-2,2-dimethyl-, trans- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1-Amino-6,6-dimethyl-2-oxo-3-oxabicyclo<3.1.0>hexane hydrochloride

: 146400-25-1,146400-42-2
(E)-1-Amino-2-(hydroxymethyl)-3,3-dimethylcyclopropane-1-carboxylic acid

Guidance literature:: With sodium hydroxide; Ambient temperature;
DOI:10.1021/jo00056a020

Reference yield: 72.0%

: 1-(tert-Butoxycarbonyl)-1-<(tert-butoxycarbonyl)amino>-2-(hydroxymethyl)-3,3-dimethylcyclopropane

: 146400-25-1,146400-42-2
(Z)-1-Amino-2-(hydroxymethyl)-3,3-dimethylcyclopropane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; 3-methyl-phenol; In 1,4-dioxane; Ambient temperature;
DOI:10.1021/jo00056a020

Reference yield:

: 146400-07-9
Malonic acid tert-butyl ester 3-methyl-but-2-enyl ester

: 146400-25-1,146400-42-2
(E)-1-Amino-2-(hydroxymethyl)-3,3-dimethylcyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / tosyl azide, K₂CO₃ / acetonitrile / Ambient temperature

2: 72 percent / CuI*P(OEt)3 / toluene / 100 - 120 °C

3: 86 percent / trifluoroacetic acid (TFA) / CH₂Cl₂ / 5 h / 0 deg C to room temperature

4: 91 percent / NEt₃, diphenylphosphoryl azide / Heating

5: 81 percent / HCl / dioxane

6: 92 percent / 2.5 M aq. NaOH / Ambient temperature

With hydrogenchloride; sodium hydroxide; 4-toluenesulfonyl azide; diphenylphosphoranyl azide; potassium carbonate; triethylamine; trifluoroacetic acid; triethylphosphite copper(I) iodide complex; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00056a020