2-(4-methylphenyl)indolizine

Base Information

• Chemical Name: 2-(4-methylphenyl)indolizine
• CAS No.: 7496-81-3
• Molecular Formula: C15H13 N
• Molecular Weight: 207.275
• Mol file: 7496-81-3.mol

Synonyms:Indolizine,2-p-tolyl- (7CI); NSC 405330

Chemical Property of 2-(4-methylphenyl)indolizine

Chemical Property:

• Melting Point: 222 °C
• PSA: 4.41000
• Density: 1.04g/cm³
• LogP: 3.91470

Purity/Quality:

99% ^*data from raw suppliers

2-(4-METHYLPHENYL)INDOLIZINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methylphenyl)indolizine

There total 8 articles about 2-(4-methylphenyl)indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

p-methylphenacyl-α-picolinium bromide (82746-47-2) → 2-(4'-methylphenyl)pyrrolo[1,2-a]pyridine (7496-81-3)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.333333h; Heating;

DOI:10.1002/jps.2600710519

Reference yield: 58.0%

α-picoline (109-06-8) + 4-(bromoacetyl)toluene (619-41-0) → 2-(4'-methylphenyl)pyrrolo[1,2-a]pyridine (7496-81-3)

Guidance literature:

α-picoline; 4-(bromoacetyl)toluene; In acetone; at 60 ℃; for 5h;

With potassium carbonate; In water; acetone; at 60 ℃; for 5h;

DOI:10.1021/acs.joc.1c00873

Reference yield: 55.0%

p-methylphenacyl-α-picolinium iodide → 2-(4'-methylphenyl)pyrrolo[1,2-a]pyridine (7496-81-3)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.166667h; Heating;

upstream raw materials:

p-methylphenacyl-α-picolinium bromide

α-picoline

4-(bromoacetyl)toluene

para-methylacetophenone

Refernces

• 1、 Cao, Hua,Lin, Jiatong,Liu, Xiang,Song, Dan,Zhan, Haiying,Zhang, Zemin,Zhuang, Canzhan. "Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions". supporting information. p. 5284 - 5288. Retrieved 2021/06/28.
• 2、 Gomes, Caroline S.,Lenard?o, Eder J.,Monzon, Loana I.,Penteado, Filipe,Perin, Gelson,Silveira, Claudio C.. "Photocatalytic Synthesis of 3-Sulfanyl- and 1,3-Bis(sulfanyl)indolizines Mediated by Visible Light". supporting information. . Retrieved 2020/04/07.