Technology Process of 2-Thiophenesulfonamide,4-ethyl-(9CI)
There total 3 articles about 2-Thiophenesulfonamide,4-ethyl-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium acetate; hydroxylamine-O-sulfonic acid;
In
water;
for 1.5h;
Ambient temperature;
DOI:10.1021/jm00094a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88percent KOH, 85percent aq. hydrazine hydrate / ethane-1,2-diol / 1 h / Heating
2: 1.) lithium, 2,2,6,6-tetramethylpiperidide, 2.) SO2 gas / 1.) THF, hexane, O deg C, 30 min, 2.) THF, hexane, 0 deg C, 30 min
3: NaOAc, H2NOSO3H / H2O / 1.5 h / Ambient temperature
With
2,2,6,6-tetramethyl-piperidine; potassium hydroxide; sulfur dioxide; sodium acetate; lithium; hydrazine hydrate; hydroxylamine-O-sulfonic acid;
In
water; ethylene glycol;
DOI:10.1021/jm00094a013
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) lithium, 2,2,6,6-tetramethylpiperidide, 2.) SO2 gas / 1.) THF, hexane, O deg C, 30 min, 2.) THF, hexane, 0 deg C, 30 min
2: NaOAc, H2NOSO3H / H2O / 1.5 h / Ambient temperature
With
2,2,6,6-tetramethyl-piperidine; sulfur dioxide; sodium acetate; lithium; hydroxylamine-O-sulfonic acid;
In
water;
DOI:10.1021/jm00094a013
